Taurine

July 9, 2020

OVERVIEW

Taurine is often referred to as an amino acid. Amino acids are the building block of proteins. But taurine is actually an amino sulfonic acid. It is not used to build protein but has many other important functions in the body. Taurine is found in large amounts in the brain, retina, heart, and blood cells called platelets. The best food sources are meat, fish, and eggs.

Taurine can be manufactured in the body of most people from other amino acids. But some people cannot make it and need to get taurine from their diet or supplements. Breast milk is rich in taurine, but infants who are not breastfed do not get enough taurine and do not have the ability to make it, so taurine is often added to infant formulas. It is also added to the formulas used for tube-feeding in adults.

People take taurine for congestive heart failure (CHF) and swelling (inflammation) of the liver (hepatitis). It is also used for athletic performance, boosting energy, diabetes, and other conditions, is but there is no good scientific evidence to support these uses.

CLASSIFICATION

Is a form of:

Amino acid

Primary Function:

Congestive heart failure

Swelling of the liver

Also Known As:

AcideAminoéthylsulfonique, AcideKétoisocaproïque de Taurine, Acid Aminoethanesulfonate

HOW DOES IT WORK?

Taurine has important functions in the heart and brain, including supporting nerve growth. It might improve heart failure because it seems to lower blood pressure and calm the sympathetic nervous system, which is often too active in people with high blood pressure and CHF.

USES

Congestive heart failure (CHF). Taurine seems to improve heart function, symptoms, and ability to exercise in people with CHF.
Swelling (inflammation) of the liver (hepatitis). Early research shows that taking taurine improves liver function in people with hepatitis.

RECOMMENDED DOSING

The following doses have been studied in scientific research:

BY MOUTH:

For congestive heart failure (CHF): 1.5-6 grams of taurine has been taken daily, divided into two or three doses.
For hepatitis: 1.5-4 grams of taurine has been taken daily for up to 3 months.

FREQUENTLY ASKED QUESTIONS:

What do taurine supplements do?

Taurine is an herbal supplement that can be used in the treatment for congestive heart failure, high blood pressure, high cholesterol, cystic fibrosis, and to prevent the buildup of plaque in the arteries throughout the body. Taurine occurs naturally in the human brain.

Does taurine give you energy?

It is also an added ingredient in some energy drinks. Some people also take taurine as a dietary supplement. Taurine is popular in the health community for its potential to help stimulate metabolism.

Is taurine good for anxiety?

L-Taurine – L-Taurine is an amino acid that plays a major role in neurotransmitter regulation, helping to calm and stabilize your mind much like GABA does. By slowing down the release of adrenaline, taurine also protects you from the fight-or-flight response and post-stress anxiety.

When should you take taurine?

Sleep: Taurine 1,000 to 2,000 mg daily before sleep. You can repeat the dose if you wake up at night to help you get back to sleep. 500mg is typically effective with other amino acids when taken before bed.

Is taurine supplement safe?

Taurine has been shown to have several health benefits, such as a lower risk of disease and improved sports performance. It is also very safe and has no known side effects when taken in reasonable doses.

When should you take taurine?

What are the symptoms of taurine deficiency?

Other symptoms include lethargy and an unhealthy skin and coat. While these symptoms are very slow to progress, if untreated Taurine deficiency can lead to permanent blindness and possibly death due to heart failure.

Can Taurine cause anxiety?

Is taurine bad for your kidneys?

The role of taurine in the pathophysiology of the kidney

Taurine has been shown to play a role in four different forms of kidney disease: glomerulonephritis, diabetic nephropathy, chronic renal failure, and acute kidney injury (AKI).

Can Taurine cause heart palpitations?

Taurine is a sulfur-containing amino acid and is the most important and abundant amino acid in the heart. Eby recommends may be too much and have heard that such a high level of Taurine can cause palpitations and high blood pressure.

Why is taurine bad for you?

Taurine is a type of amino acid found in many foods and often added to energy drinks. Taurine has been shown to have several health benefits, such as a lower risk of disease and improved sports performance). It is also very safe and has no known side effects when taken in reasonable doses.

Will taurine keep me awake?

Taurine 1000-2000mg daily before sleep. You can repeat the dose if you wake up at night to help you get back to sleep. L-tryptophan, taken with taurine, helps promote sleep. Taurine has a calming effect and L-tryptophan has a more hypnotic effect.

Does taurine increase testosterone?

The results indicated that taurine can enhance the sexual response and mating ability in aged male rats by increasing the level of testosterone and NO, but the exact mechanism of which needs to be further investigated.

Does taurine increase serotonin?

Taurine also increases synthesis of dopamine. 6.2 Serotonergic interactions: It decreases the serotonin turnover in hypothalamus. Taurine induced hypothermia is reduced if brain serotonin content is lowered by p-chlorophenylamine treatment.

Can you take taurine before bed?

Is taurine anti-inflammatory?

Taurine has been shown to increase muscle function and importantly to protect muscles from necrosis in the mdx mouse model of DMD. We propose that taurine exerts an anti-inflammatory and antioxidant action by preventing damage caused by hypochlorous acid (HOCl) generated by inflammatory cells, particularly neutrophils.

Who should not take taurine?

Stay on the safe side and avoid use. Children: Taurine is LIKELY SAFE for children when used in amounts found in foods. Taurine is POSSIBLY SAFE for children when used as a medicine for up to 4 months. Bipolar disorder: There is some concern that taking too much taurine might make bipolar disorder worse.

What foods are highest in taurine?

The highest amounts of taurine can be found in shellfish, especially scallops, mussels, and clams. High amounts of taurine can also be found in the dark meat of turkey and chicken, and turkey bologna.

What blocks taurine absorption?

When high protein legumes are used in pet food, less animal protein is necessary to meet the formula requirements. Essentially, plant proteins that do not contain taurine and actually block taurine absorption, are being substituted for animal proteins which are high in taurine.

CLINICAL STUDIES

^ a b Pansani MC, et al. Atrophic cardiac remodeling induced by taurine deficiency in Wistar rats. PLoS One. (2012)
^ a b Jacobsen JG, Smith LH. Biochemistry and physiology of taurine and taurine derivatives. Physiol Rev. (1968)
^ Higuchi M, et al. Taurine plays an important role in the protection of spermatogonia from oxidative stress. Amino Acids. (2012)
^ a b c d e f Yang J, et al. Effects of taurine on male reproduction in rats of different ages. J Biomed Sci. (2010)
^ Huxtable RJ. Physiological actions of taurine. Physiol Rev. (1992)
^ a b Uchida S, et al. Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(-)-dependent taurine transporter that is regulated by hypertonicity. Proc Natl Acad Sci U S A. (1992)
^ Bouckenooghe T, Remacle C, Reusens B. Is taurine a functional nutrient. Curr Opin Clin Nutr Metab Care. (2006)
^ a b c d e Zhang CG, Kim SJ. Taurine induces anti-anxiety by activating strychnine-sensitive glycine receptor in vivo. Ann Nutr Metab. (2007)
^ Chapman RA, Suleiman MS, Earm YE. Taurine and the heart. Cardiovasc Res. (1993)
^ Chesney RW. Taurine: its biological role and clinical implications. Adv Pediatr. (1985)
^ a b Jong CJ, et al. Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content. J Biomed Sci. (2010)
^ a b c d Ito T, et al. Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice. J Biomed Sci. (2010)
^ Sturman JA. Dietary taurine and feline reproduction and development. J Nutr. (1991)
^ Pion PD, et al. Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy. Science. (1987)
^ Lake N. Loss of cardiac myofibrils: mechanism of contractile deficits induced by taurine deficiency. Am J Physiol. (1993)
^ Cuisinier C, et al. Effects of guandinoethane sulfonate on contraction of skeletal muscle. Adv Exp Med Biol. (2000)
^ Ito T, et al. Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy. J Mol Cell Cardiol. (2008)
^ Warskulat U, et al. Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised. FASEB J. (2004)
^ a b c Purchas RW, Busboom JR, Wilkinson BH. Changes in the forms of iron and in concentrations of taurine, carnosine, coenzyme Q(10), and creatine in beef longissimus muscle with cooking and simulated stomach and duodenal digestion. Meat Sci. (2006)
^ Petrosian AM, Haroutounian JE. Taurine as a universal carrier of lipid soluble vitamins: a hypothesis. Amino Acids. (2000)
^ Nakashima T, et al. Taurine in the liver. The function of taurine conjugated with bile acids. Adv Exp Med Biol. (1996)
^Study of taurine and tauret content in the compound eye of locust with light and dark adaptation.
^ a b Petrosian AM, Haroutounian JE, Zueva LV. A taurine-related endogenous substance in the retina and its role in vision. Adv Exp Med Biol. (1996)
^ a b Frosini M, et al. Interactions of taurine and structurally related analogues with the GABAergic system and taurine binding sites of rabbit brain. Br J Pharmacol. (2003)
^ a b c Suárez LM, Solís JM. Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons. Eur J Neurosci. (2006)
^ Paquet M, et al. AMPA and NMDA glutamate receptor subunits in midbrain dopaminergic neurons in the squirrel monkey: an immunohistochemical and in situ hybridization study. J Neurosci. (1997)
^Regional, cellular, and ultrastructural distribution of N-methyl-D-aspartate receptor subunit 1 in monkey hippocampus.
^ Mameli M, et al. Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors. J Neurosci. (2005)
^ Bardoni R, et al. Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn. J Neurosci. (2004)
^ Fiszman ML, et al. NMDA receptors increase the size of GABAergic terminals and enhance GABA release. J Neurosci. (2005)
^ Banerjee SP, et al. Neuropsychopharmacological actions of taurine. Adv Exp Med Biol. (2013)
^ a b c d Chan CY, et al. Direct interaction of taurine with the NMDA glutamate receptor subtype via multiple mechanisms. Adv Exp Med Biol. (2013)
^ a b c d Iio W, et al. The effects of oral taurine administration on behavior and hippocampal signal transduction in rats. Amino Acids. (2012)
^ a b c Toyoda A, Iio W. Antidepressant-like effect of chronic taurine administration and its hippocampal signal transduction in rats. Adv Exp Med Biol. (2013)
^ Yakimova K, et al. Effects of GABA agonists and antagonists on temperature-sensitive neurones in the rat hypothalamus. J Physiol. (1996)
^ Barbeau A, et al. The neuropharmacology of taurine. Life Sci. (1975)
^ Kuriyama K, Hashimoto T. Interrelationship between taurine and GABA. Adv Exp Med Biol. (1998)
^ Bureau MH, Olsen RW. Taurine acts on a subclass of GABAA receptors in mammalian brain in vitro. Eur J Pharmacol. (1991)
^ Kontro P, Oja SS. Interactions of taurine with GABAB binding sites in mouse brain. Neuropharmacology. (1990)
^ Smith SS, Li J. GABAB receptor stimulation by baclofen and taurine enhances excitatory amino acid induced phosphatidylinositol turnover in neonatal rat cerebellum. Neurosci Lett. (1991)
^ Sarup A, Larsson OM, Schousboe A. GABA transporters and GABA-transaminase as drug targets. Curr Drug Targets CNS Neurol Disord. (2003)
^ Pericić D, Manev H, Bujas M. Gonadal hormones and picrotoxin-induced convulsions in male and female rats. Brain Res. (1996)
^ Yang P, et al. Alterations of amino Acid level in depressed rat brain.. Korean J Physiol Pharmacol. (2014)
^ Haas HL, Hösli L.. The depression of brain stem neurones by taurine and its interaction with strychnine and bicuculline.. Brain Res. (1973)
^New approaches to antidepressant drug discovery: beyond monoamines.
^ Iio W, et al. Effects of chronic social defeat stress on MAP kinase cascade. Neurosci Lett. (2011)
^ Ryan J. Anderson, et al. The Prevalence of Comorbid Depression in Adults With Diabetes - A meta-analysis. Diabetes Care. (2001)
^ a b c Caletti G, et al. Antidepressant dose of taurine increases mRNA expression of GABAA receptor α2 subunit and BDNF in the hippocampus of diabetic rats.. Behav Brain Res.. (2015)
^ Rosane Gomez, et al. Lower in vivo brain extracellular GABA concentration in diabetic rats during forced swimming. Brain Research. (2003)
^ Vollenweider I, et al. Antidepressant-like properties of α2-containing GABA(A) receptors.. Behav Brain Res. (2011)
^ Ming He, Jikun Wang. Decreased serum brain-derived neurotrophic factor in Chinese patients with Type 2 diabetes mellitus. Acta Bio. (2014)
^ Caletti G, et al. Antidepressant effect of taurine in diabetic rats.. Amino Acids. (2012)
^ Park JY, You JS, Chang KJ. Dietary taurine intake, nutrients intake, dietary habits and life stress by depression in Korean female college students: a case-control study. J Biomed Sci. (2010)
^ Sung MJ, Chang KJ. Correlations between dietary taurine intake and life stress in Korean college students.. Adv Exp Med Biol. (2009)
^ Park SY, You JS, Chang KJ. Relationship among self-reported fatigue, dietary taurine intake, and dietary habits in Korean college students.. Adv Exp Med Biol.. (2013)
^ You JS, Park JY, Chang KJ. A case-control study on the dietary taurine intake, nutrient status and life stress of functional constipation patients in Korean male college students.. J Biomed Sci. (2010)
^ Trachtman H, et al. Taurine attenuates renal disease in chronic puromycin aminonucleoside nephropathy. Am J Physiol. (1992)
^ Wu QD, et al. Taurine prevents high-glucose-induced human vascular endothelial cell apoptosis. Am J Physiol. (1999)
^ a b Effects of Taurine on Biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats.
^ Hanna J, et al. Protective effect of taurine against free radicals damage in the rat myocardium. Exp Toxicol Pathol. (2004)
^ Kingston R, Kelly CJ, Murray P. The therapeutic role of taurine in ischaemia-reperfusion injury. Curr Pharm Des. (2004)
^ Baek YY, et al. Extracellular taurine induces angiogenesis by activating ERK-, Akt-, and FAK-dependent signal pathways. Eur J Pharmacol. (2012)
^ Moloney MA, et al. Two weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics. Diab Vasc Dis Res. (2010)
^ Nandhini AT, Thirunavukkarasu V, Anuradha CV. Taurine modifies insulin signaling enzymes in the fructose-fed insulin resistant rats. Diabetes Metab. (2005)
^ Nandhini AT, Anuradha CV. Taurine modulates kallikrein activity and glucose metabolism in insulin resistant rats. Amino Acids. (2002)
^ Catena C, et al. Cellular mechanisms of insulin resistance in rats with fructose-induced hypertension. Am J Hypertens. (2003)
^Taurine prevents collagen abnormalities in high-fructose fed rats.
^ Devamanoharan PS, Ali AH, Varma SD. Oxidative stress to rat lens in vitro: protection by taurine. Free Radic Res. (1998)
^ Ra SG, et al. Additional effects of taurine on the benefits of BCAA intake for the delayed-onset muscle soreness and muscle damage induced by high-intensity eccentric exercise. Adv Exp Med Biol. (2013)
^ a b Rutherford JA, Spriet LL, Stellingwerff T. The effect of acute taurine ingestion on endurance performance and metabolism in well-trained cyclists. Int J Sport Nutr Exerc Metab. (2010)
^ Balshaw TG, et al. The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners. Amino Acids. (2012)
^ Lobo MV, Alonso FJ, del Río RM. Immunohistochemical localization of taurine in the male reproductive organs of the rat. J Histochem Cytochem. (2000)
^ Jana K, Samanta PK, De DK. Nicotine diminishes testicular gametogenesis, steroidogenesis, and steroidogenic acute regulatory protein expression in adult albino rats: possible influence on pituitary gonadotropins and alteration of testicular antioxidant status. Toxicol Sci. (2010)
^ Das J, et al. Taurine protects rat testes against NaAsO(2)-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett. (2009)
^ Manna P, Sinha M, Sil PC. Cadmium induced testicular pathophysiology: prophylactic role of taurine. Reprod Toxicol. (2008)
^ Das J, et al. Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis. Amino Acids. (2012)
^ Shrilatha B, Muralidhara. Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice: its progression and genotoxic consequences. Reprod Toxicol. (2007)
^ Tsounapi P, et al. Antioxidant treatment with edaravone or taurine ameliorates diabetes-induced testicular dysfunction in the rat. Mol Cell Biochem. (2012)
^ a b c Yang J, et al. CSD mRNA expression in rat testis and the effect of taurine on testosterone secretion. Amino Acids. (2010)
^ a b Ratamess NA, et al. Effects of an amino acid/creatine energy supplement on the acute hormonal response to resistance exercise. Int J Sport Nutr Exerc Metab. (2007)
^ Aruoma OI, et al. The antioxidant action of taurine, hypotaurine and their metabolic precursors. Biochem J. (1988)
^ Schaffer SW, et al. Physiological roles of taurine in heart and muscle. J Biomed Sci. (2010)
^ a b Jong CJ, Azuma J, Schaffer S. Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids. (2012)
^ Ricci C, et al. Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis. Am J Physiol Cell Physiol. (2008)
^Mitochondrial formation of reactive oxygen species.
^ Schaffer SW, Azuma J, Mozaffari M. Role of antioxidant activity of taurine in diabetes. Can J Physiol Pharmacol. (2009)
^ Gondo Y, et al. Effect of taurine on mRNA expression of thioredoxin interacting protein in Caco-2 cells. Biochem Biophys Res Commun. (2012)
^Retinal morphology and visual pigment levels in 6-and 12-month-old rhesus monkeys fed a taurine-free human infant formula.
^Retinal degeneration in primates raised on a synthetic human infant formula.
^ Schmidt SY, Berson EL, Hayes KC. Retinal degeneration in cats fed casein. I. Taurine deficiency. Invest Ophthalmol. (1976)
^ Hayes KC, Carey RE, Schmidt SY. Retinal degeneration associated with taurine deficiency in the cat. Science. (1975)
^ Quesada O, Huxtable RJ, Pasantes-Morales H. Effect of guanidinoethane sulfonate on taurine uptake by rat retina. J Neurosci Res. (1984)
^ Pasantes-Morales H, et al. Effects of the taurine transport antagonist, guanidinoethane sulfonate, and beta-alanine on the morphology of rat retina. J Neurosci Res. (1983)
^ Petrosian AM, et al. New HPLC evidence on endogenous tauret in retina and pigment epithelium. Adv Exp Med Biol. (2000)
^ Petrosian AM, Poghosyan LA, Haroutounian JE. Study of taurine and tauret content in the compound eye of locust with light and dark adaptation. Amino Acids. (2006)
^ Altshuler D, et al. Taurine promotes the differentiation of a vertebrate retinal cell type in vitro. Development. (1993)
^ Pasantes-Morales H, Morán J, Schousboe A. Taurine release associated to cell swelling in the nervous system. Prog Clin Biol Res. (1990)
^ Petrosian AM, Haroutounian JE. The role of taurine in osmotic, mechanical, and chemical protection of the retinal rod outer segments. Adv Exp Med Biol. (1998)
^ Son HY, Kim H, H Kwon Y. Taurine prevents oxidative damage of high glucose-induced cataractogenesis in isolated rat lenses. J Nutr Sci Vitaminol (Tokyo). (2007)
^ a b Potential therapeutic effect of antioxidants in experimental diabetic retina: a comparison between chronic taurine and vitamin E plus selenium supplementations.
^ Guz G, et al. The effect of taurine on renal ischemia/reperfusion injury. Amino Acids. (2007)
^ Tabassum H, et al. Nephrotoxicity and its prevention by taurine in tamoxifen induced oxidative stress in mice. Hum Exp Toxicol. (2007)
^ Manna P, Sinha M, Sil PC. Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction. Amino Acids. (2009)
^ Trachtman H, et al. Taurine ameliorates chronic streptozocin-induced diabetic nephropathy in rats. Am J Physiol. (1995)
^ Schuller-Levis G, et al. Taurine protects against oxidant-induced lung injury: possible mechanism(s) of action. Adv Exp Med Biol. (1994)
^ Acharya M, Lau-Cam CA. Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat. J Biomed Sci. (2010)
^ Sinha M, Manna P, Sil PC. Taurine, a conditionally essential amino acid, ameliorates arsenic-induced cytotoxicity in murine hepatocytes. Toxicol In Vitro. (2007)
^ a b Warskulat U, et al. Ultraviolet A induces transport of compatible organic osmolytes in human dermal fibroblasts. Exp Dermatol. (2008)
^ Shao A, Hathcock JN. Risk assessment for the amino acids taurine, L-glutamine and L-arginine. Regul Toxicol Pharmacol. (2008)
Beyranvand MR, et al. Effect of taurine supplementation on exercise capacity of patients with heart failure. J Cardiol. (2011)
Bahadoran Z, et al. The Nitrate-Independent Blood Pressure-Lowering Effect of Beetroot Juice: A Systematic Review and Meta-Analysis. Adv Nutr. (2017)
Lara J, et al. Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis. Eur J Nutr. (2016)
Aune D, et al. Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality-a systematic review and dose-response meta-analysis of prospective studies. Int J Epidemiol. (2017)
Ried K. Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and Review. J Nutr. (2016)
Ried K, Toben C, Fakler P. Effect of garlic on serum lipids: an updated meta-analysis. Nutr Rev. (2013)
El Asmar MS, Naoum JJ, Arbid EJ. Vitamin k dependent proteins and the role of vitamin k2 in the modulation of vascular calcification: a review. Oman Med J. (2014)
Knapen MH, et al. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost. (2015)
Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc.
Cockayne S, et al. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med. (2006)
Kodama S, et al. Fasting and post-challenge glucose as quantitative cardiovascular risk factors: a meta-analysis. J Atheroscler Thromb. (2012)
Mannucci E, et al. Is glucose control important for prevention of cardiovascular disease in diabetes?. Diabetes Care. (2013)
Lan J, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. (2015)
Ahmadian M, Dabidi Roshan V, Ashourpore E. Taurine Supplementation Improves Functional Capacity, Myocardial Oxygen Consumption, and Electrical Activity in Heart Failure. J Diet Suppl. (2017)
Ahmadian M, et al. Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure. Ther Adv Cardiovasc Dis. (2017)
Sun Q, et al. Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. Hypertension. (2016)
Militante JD, Lombardini JB. Treatment of hypertension with oral taurine: experimental and clinical studies. Amino Acids. (2002)