Ribose is a kind of sugar that is produced by the body. It is used as a medicine.

Ribose is used by mouth to decrease chest pain and improve heart function in people with coronary artery disease. It is also sometimes used by mouth to improve mental function, athletic performance, symptoms of chronic fatigue syndrome (CFS), fibromyalgia, and exercise performance and recovery in people with certain genetic diseases. But there is only limited scientific research to support these uses.

Healthcare providers sometimes give ribose through the vein (by IV) as part of a procedure used to measure the extent of damaged heart muscle in people with coronary artery disease.


Is a Form of:


Primary Functions:

Chest pain, heart function

Also Known As:

Beta-D-ribofuranose, D-ribosa, D-ribose, Ribosa.

How Does It Work?

Ribose is an energy source that the body makes from food. There is some evidence that supplemental ribose might prevent muscle fatigue in people with genetic disorders that prevent sufficient energy production by the body. It might provide extra energy to the heart during exercise in people with heart disease.


  • Clogged heart arteries (coronary artery disease). Giving ribose through the vein (by IV) seems to improve the heart's ability to contract in people with coronary artery disease. Taking ribose by mouth seems to be effective for decreasing chest pain and improving the heart's ability to manage low blood flow in people with coronary artery disease.
  • Congestive heart failure (CHF). Taking ribose by mouth seems to improve quality of life and some measures of heart function in people with congestive heart failure.

Recommended Dosing

The following doses have been studied in scientific research:



  • For clogged heart arteries (coronary artery disease): 60 grams daily for 3 days has been taken under the direction of a healthcare provider.
  • Congestive heart failure (CHF): 5 grams three times daily has been taken for up to 8 weeks.


  • For clogged heart arteries (coronary artery disease): A 10% ribose solution may be given at a dose determined by a healthcare provider.

Ribose Supplements Frequently Asked Questions

What foods are high in ribose?

Ribose can be found in both plants and animals, including:

  • Beef and poultry.
  • Cheddar cheese and cream cheese.
  • Anchovies, herring, and sardines.

When should you take D Ribose?

It is critical to use the proper dose for the first 3 weeks, which is 5 grams (5,000 mg) three times a day. It can then be dropped to twice a day. Because of its importance, it's worth looking at energy production and ribose in greater detail.

Does ribose cause weight gain?

Here we show that ribose upregulates gut motility and suppresses mice body weight gain. The suppressed weight gain was resulted from enhanced ingested food excretion. In addition, the effective dose of ribose didn't cause any known side effects (i.e. diarrhea and hypoglycemia).

Does D Ribose raise blood pressure?

Taking D-Ribose has shown that this can return normal heart function within two days. This is especially true in people with high blood pressure where the heart is having to use a lot of energy to pump blood around the body, and taking D-Ribose increases heart energy reserves and may help restore cardiac dysfunction.

Is ribose safe to take?

Ribose seems to be LIKELY SAFE for most people when taken by mouth for short-term use or when given intravenously (by IV) by a healthcare provider. It can cause some side effects including diarrhea, stomach discomfort, nausea, headache, and low blood sugar.

How long does it take for D Ribose to start working?

A recent study showed that in people with chronic fatigue and fibromyalgia, ribose increased energy an average of 45% in just 3 weeks. It looks and tastes like sugar. Dose is 1 scoop (5 grams) 3x a day for 3 weeks and then 2x a day. Give it 3 weeks to work.

Does D Ribose really work?

Evidence suggests that D-ribose may improve energy production in heart muscle, as it's essential for ATP production (2, 3). Overall, studies demonstrate the potential of D-ribose for improving heart metabolism and function in people with heart disease (3, 6, 7).

Can D Ribose cause anxiety?

In contrast, gavage of D-Ribose resulted not only in high levels of Aβ-like deposition and Tau phosphorylation in the hippocampus, but also in memory loss and anxiety-like behavior. The long-term administration of D-Ribose did not cause any significant changes in the body weight compared to mice treated with D-Glucose.

What does ribose do for the body?

Ribose is a kind of sugar that is produced by the body. It is used as a medicine. Ribose is used by mouth to decrease chest pain and improve heart function in people with coronary artery disease.

Can D Ribose make you tired?

But ribose is not like any other sugar. Research has repeatedly shown that giving ribose to energy-deficient hearts and muscles stimulates energy recovery. A recent study showed that in people with chronic fatigue and fibromyalgia, ribose increased energy an average of 45% in just 3 weeks.

How much D Ribose should I take?

It's been determined that single doses of 10 grams of D-ribose are safe and generally well-tolerated by healthy adults (24). However, higher doses were used in most of the studies discussed in this article.

Can I take D Ribose at night?

Sleep, pain, mental clarity and overall well-being also improved by taking D-ribose supplements. Millions of Americans suffer from fibromyalgia and chronic fatigue syndrome (CFS), and some of their symptoms overlap. 37% increase in overall well-being. 29% improvement in sleep.

What are the side effects of D Ribose?

D-ribose is generally considered safe for short-term use. However, possible side effects include diarrhea, stomach discomfort, nausea, headache, and low blood sugar.

Is D Ribose safe for diabetics?

Stay on the safe side and avoid use. Diabetes: Ribose might lower blood sugar. When used along with diabetes medications that lower blood sugar, it might make blood sugar drop too low. It's best not to use ribose if you have diabetes.

Is D Ribose good for fibromyalgia?

D-ribose is a supplement that's sometimes recommended as a treatment for people with fibromyalgia and chronic fatigue syndrome. D-ribose plays several important roles in your body, such as: Helping produce energy in the form of ATP (adenosine triphosphate)

What is D Ribose supplement made from?

Ribose is a sugar molecule that occurs naturally in the body and is made from blood glucose. It is a key component of adenosine triphosphate (ATP), a molecule involved in storing and releasing energy, and ribonucleic acid (RNA), a molecule involved in protein synthesis and other cell activities.

What is the difference between ribose and glucose?

Ring Structure for Ribose:

The chair form of ribose follows a similar pattern as that for glucose with one exception. Since ribose has an aldehyde functional group, the ring closure occurs at carbon # 1, which is the same as glucose. The exception is that ribose is a pentose, five carbons.

Is Ribose a aldose or ketose?

Hexoses. Glucose, mannose, galactose (all aldoses), and fructose (ketose) Pentoses. Ribose, xylose (both aldoses)

Is D Ribose made from corn?

D-ribose is derived from corn and some CFSs who are corn sensitive will react allergically to it.

Is Ribose a sugar?

Ribose & deoxyribose sugars. Ribose is a single-ring pentose [5-Carbon] sugar. The numbering of the carbon atoms runs clockwise, following organic chemistry rules.

Is Ribose a five carbon sugar?

The 5-carbon sugars ribose and deoxyribose are important components of nucleotides, and are found in RNA and DNA, respectively. The sugars found in nucleic acids are pentose sugars; a pentose sugar has five carbon atoms.

Clinical Studies