Chromium
Overview
Chromium is a mineral. It is called an "essential trace element" because very small amounts of chromium are necessary for human health. There are two forms of chromium: trivalent chromium and hexavalent chromium. The first is found in foods and supplements and is safe for humans. The second is a known toxin that can cause skin problems and lung cancer.
Chromium is used for chromium deficiency. It is also used for diabetes, high cholesterol, a hormonal disorder that causes enlarged ovaries with cysts (polycystic ovary syndrome or PCOS), and many other conditions, but there is no good scientific evidence to support most of these uses.
Classification
Is a Form of:
Mineral
Primary Functions:
Chromium deficiency
Also Known As:
Acétate de Chrome, Atomic Number 24, Chlorure Chromique
How Does It Work?
Chromium might help keep blood sugar levels normal by improving the way our bodies use insulin.
Uses
- Chromium deficiency.Taking chromium by mouth is effective for preventing chromium deficiency.
- Diabetes. Taking chromium picolinate may lower fasting blood sugar and insulin levels in some people with type 2 diabetes. Chromium picolinate might also decrease weight gain in people taking a class of antidiabetes medications called sulfonylureas. Higher chromium doses might work better and faster than lower doses. Higher doses might also lower the level of certain blood fats (cholesterol and triglycerides) in some people with diabetes. Early research shows that chromium picolinate might have the same benefits in people with type 1 diabetes, people who have diabetes as a result of steroid treatment, and people with diabetes that develops during pregnancy. But chromium might not help everyone. Some researchers think that chromium supplements only benefit people with low chromium levels or malnutrition. Most people with diabetes don't have low chromium levels. Chromium might also help prevent diabetes. But research is limited.
- High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Some research shows that taking 15-200 mcg of chromium daily for 6-12 weeks lowers low-density lipoprotein (LDL or "bad") cholesterol and total cholesterol levels in people with slightly high or high cholesterol levels. Other research suggests that taking chromium for 7-16 months lowers triglycerides and LDL and increases high-density lipoprotein (HDL or "good") cholesterol. Also, taking chromium alone or along with other supplements seems to reduce levels of blood fats in people with high blood fat levels. However, there is some evidence that taking chromium daily for 10 weeks does not improve cholesterol levels in postmenopausal women.
Recommended Dosing
The following doses have been studied in scientific research:
ADULTS
BY MOUTH:
- General: The safe and tolerable upper intake levels of chromium are not known. However, daily adequate intake (AI) levels for chromium have been established: men 14 to 50 years, 35 mcg; men 51 and older, 30 mcg; women 19 to 50 years, 25 mcg; women 51 and older, 20 mcg; pregnant women 14 to 18 years, 29 mcg; 19 to 50 years, 30 mcg; breast-feeding women 14 to 18 years, 44 mcg; 19 to 50 years, 45 mcg.
- For diabetes: In people with type 2 diabetes, 200-1000 mcg of chromium taken daily in single or divided doses has been used. Also, a specific combination product providing chromium 600 mcg plus biotin 2 mg daily (Diachrome by Nutrition 21) has been used for up to 3 months. In addition, 1000 mcg of chromium (as chromium yeast) together with 1000 mg of vitamin C and 800 IU of vitamin E daily for 6 months has been used. In people with gestational diabetes, 4-8 mcg/kg of chromium picolinate daily for 8 weeks has been used. In people with high blood sugar due to use of corticosteroid medication, 400 mcg of chromium once daily or 200 mcg three times daily has been used.
- For high levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia): 50-250 mcg of chromium as chromium chloride or chromium picolinate, or brewer's yeast containing 15-48 mcg of chromium, has been used 5-7 days weekly for up to 16 months. 200 mcg of chromium polynicotinate along with 100 mg of grape seed extract, taken twice daily for 2 months, has been used. One to two capsules of a specific supplement (Colenon) containing 240 mg of chitosan, 55 mg of Garcinia cambogia extract, and 19 mg of chromium taken daily for 4 weeks has been used.
CHILDREN
BY MOUTH:
- General: The safe and tolerable upper intake levels of chromium in children are not known. However, daily adequate intake (AI) levels for chromium have been established: Infants 0 to 6 months, 0.2 mcg; 7 to 12 months, 5.5 mcg; children 1 to 3 years, 11 mcg; 4 to 8 years, 15 mcg; boys 9 to 13 years, 25 mcg; boys 14-18 years. 35 mcg; girls 9 to 13 years, 21 mcg; 14 to 18 years, 24 mcg.
- For high levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia): 400-600 mcg of chromium polynicotinate and 1000-1500 mg of glucomannan has been used twice daily for 8 weeks.
Chromium Supplements Frequently Asked Questions
What does chromium do to your body?
Chromium is a mineral that humans require in trace amounts. Chromium is known to enhance the action of insulin and also appears to be directly involved in carbohydrate, fat, and protein metabolism. Chromium stores in the body may be reduced under several conditions.
Are chromium supplements safe?
Cautions about supplements
Chromium deficiency is rare, and studies have not yet confirmed the benefits of taking supplements, so it is best to obtain chromium through food. However, large doses of chromium in supplement form can cause stomach problems, low blood sugar, and kidney or liver damage.
Does chromium help with weight loss?
So there are claims that chromium supplements can lower your appetite, help you burn more calories, cut your body fat, and boost your muscle mass. But a review of 24 studies that checked the effects of 200-1,000 micrograms of chromium a day found that there aren't any significant benefits.
Does chromium have side effects?
Chromium has been used safely in a small number of studies using doses of 200-1000 mcg daily for up to 2 years. Some people experience side effects such as skin irritation, headaches, dizziness, nausea, mood changes, impaired thinking, judgment, and coordination.
Does chromium burn belly fat?
Chromium is a mineral that enhances insulin, a hormone that's important for turning food into energy. Your body also needs it to store carbohydrates, fats, and proteins. So there are claims that chromium supplements can lower your appetite, help you burn more calories, cut your body fat, and boost your muscle mass.
What are the benefits of cinnamon and chromium?
Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes.
Can chromium cause depression?
For example, one study showed that chromium may affect symptoms such as increased appetite and eating, carbohydrate cravings, and diurnal mood variation, a type of depression in which symptoms are worse in the morning but improve as the day goes on.
Where is chromium found in food?
Some of the best sources of chromium are broccoli, liver and brewer's yeast. Potatoes, whole grains, seafood, and meats also contain chromium.
Should I take chromium?
When taken by mouth: Chromium is LIKELY SAFE for most adults in medicinal amounts, short-term. Up to 1000 mcg per day of chromium has been used safely for up to 6 months. When taken by mouth in these doses for longer periods of time, chromium is POSSIBLY SAFE for most adults.
Does chromium make you poop?
Benefits and risks of chromium supplements
Chromium picolinate is a popular supplement often marketed to those wanting to build muscle or lose weight. Some of those taking the supplement also experienced side effects, including watery stool, vertigo, headaches, and hives.
What is the best chromium to take for weight loss?
Doses of up to 1,000 μg/day of chromium picolinate were used in these studies. Overall, this research found that chromium picolinate produced very small amounts of weight loss (2.4 pounds or 1.1 kg) after 12 to 16 weeks in overweight or obese adults.
Is chromium bad for your liver?
There have been no reported cases of chromium poisoning due to food intake, so the IOM has not fixed a maximum intake level. However, large doses of chromium in supplement form can cause stomach problems, low blood sugar, and kidney or liver damage.
Does chromium help blood sugar?
Chromium picolinate, specifically, has been shown to reduce insulin resistance and to help reduce the risk of cardiovascular disease and type 2 diabetes. Dietary chromium is poorly absorbed. Supplements containing 200-1,000 mcg chromium as chromium picolinate a day have been found to improve blood glucose control.
What's the difference between chromium and chromium picolinate?
However, chromium picolinate is an alternate form of chromium that is absorbed better. For this reason, this type is commonly found in dietary supplements. Chromium picolinate is the mineral chromium attached to three molecules of picolinic acid.
What are the signs of chromium deficiency?
Signs and symptoms
The claimed symptoms of chromium deficiency caused by long-term total parenteral nutrition are severely impaired glucose tolerance, weight loss, peripheral neuropathy and confusion.
Does chromium cause anxiety?
Behavioral or psychiatric conditions such as depression, anxiety, or schizophrenia: Chromium might affect brain chemistry and might make behavioral or psychiatric conditions worse. If you have one of these conditions, be careful when using chromium supplements. Pay attention to any changes in how you feel.
Which form of chromium is toxic?
Trivalent chromium, or chromium(III), is the form of chromium that is essential to human health. Hexavalent chromium, or chromium(VI), is an unequivocally toxic form.
How much chromium should I take?
In the United States, the recommended dietary reference intake (DRI) of chromium is 35 μg/day for adult men and 25 μg/day for adult women (20). After the age of 50, the recommended intake decreases slightly to 30 μg/day for men and 20 μg/day for women.
Do eggs have chromium?
Chromium is commonly found in egg yolk, whole grains, high-bran cereals, green beans, broccoli, nuts, and brewer's yeast.
What is chromium in food?
Processed meats, whole-grain products, high-bran cereals, green beans, broccoli, nuts, and egg yolk are good sources of chromium. Foods high in simple sugars, such as sucrose and fructose, are usually low in chromium and may actually promote chromium excretion (4).
How do you get chromium in your diet?
Foods that are good sources of chromium include:
- Vegetables such as broccoli, potatoes, and green beans.
- Whole-grain products.
- Beef and poultry.
- Fruits, including apples and bananas; grape juice.
- Milk and dairy products.
Clinical Studies
- ^ a b Parsons A, et al. A proof of concept randomised placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to prevent weight gain on smoking cessation. Drug Alcohol Depend. (2009)
- ^ a b c d Lukaski HC. Chromium as a supplement. Annu Rev Nutr. (1999)
- ^ a b c Yamamoto A, Wada O, Suzuki H. Purification and properties of biologically active chromium complex from bovine colostrum. J Nutr. (1988)
- ^ Yamamoto A, Wada O, Suzuki H. Separation of biologically active chromium complex from cow colostrum. Tohoku J Exp Med. (1987)
- ^ a b Hexavalent Chromium.
- ^ a b c Trumbo P, et al. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. J Am Diet Assoc. (2001)
- ^ Iyengar V, Woittiez J. Trace elements in human clinical specimens: evaluation of literature data to identify reference values. Clin Chem. (1988)
- ^ a b Freund H, Atamian S, Fischer JE. Chromium deficiency during total parenteral nutrition. JAMA. (1979)
- ^ a b Jeejeebhoy KN, et al. Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long-term total parenteral nutrition. Am J Clin Nutr. (1977)
- ^ Davies S, et al. Age-related decreases in chromium levels in 51,665 hair, sweat, and serum samples from 40,872 patients--implications for the prevention of cardiovascular disease and type II diabetes mellitus. Metabolism. (1997)
- ^ Sundararaman PG, et al. Serum chromium levels in gestational diabetes mellitus. Indian J Endocrinol Metab. (2012)
- ^ Woods SE, et al. Serum chromium and gestational diabetes. J Am Board Fam Med. (2008)
- ^ Kozlovsky AS, et al. Effects of diets high in simple sugars on urinary chromium losses. Metabolism. (1986)
- ^ Hajifaraji M, Leeds AR. The effect of high and low glycemic index diets on urinary chromium in healthy individuals: a cross-over study. Arch Iran Med. (2008)
- ^ a b c d Vincent JB. The biochemistry of chromium. J Nutr. (2000)
- ^ Davis CM, Vincent JB. Isolation and characterization of a biologically active chromium oligopeptide from bovine liver. Arch Biochem Biophys. (1997)
- ^ a b Clodfelder BJ, et al. The trail of chromium(III) in vivo from the blood to the urine: the roles of transferrin and chromodulin. J Biol Inorg Chem. (2001)
- ^ Anderson RA, et al. Urinary chromium excretion of human subjects: effects of chromium supplementation and glucose loading. Am J Clin Nutr. (1982)
- ^ a b Anderson RA, et al. Effect of Exercise (Running) on Serum Glucose, Insulin, Glucagon, and Chromium Excretion. Diabetes. (1982)
- ^ Wahren J, et al. Glucose metabolism during leg exercise in man. J Clin Invest. (1971)
- ^ a b Bagchi D, et al. Comparative induction of oxidative stress in cultured J774A.1 macrophage cells by chromium picolinate and chromium nicotinate. Res Commun Mol Pathol Pharmacol. (1997)
- ^ Wise SS, Holmes AL, Wise JP Sr. Hexavalent chromium-induced DNA damage and repair mechanisms. Rev Environ Health. (2008)
- ^ Zhang XH, et al. Chronic occupational exposure to hexavalent chromium causes DNA damage in electroplating workers. BMC Public Health. (2011)
- ^ Kingry KF, Royer AC, Vincent JB. Nuclear magnetic resonance studies of chromium(III) pyridinecarboxylate complexes. J Inorg Biochem. (1998)
- ^ Stearns DM, Armstrong WH. Mononuclear and binuclear chromium(III) picolinate complexes. Inorg Chem. (1992)
- ^ Yuen G, Heaster H, Hoggard PE. Amine spectrochemical properties in tris(aminocarboxylate) complexes of chromium(III). Inorg Chim Acta. (1983)
- ^ a b c Speetjens JK, et al. The nutritional supplement chromium(III) tris(picolinate) cleaves DNA. Chem Res Toxicol. (1999)
- ^ Raspor P, et al. The influence of chromium compounds on yeast physiology (a review). Acta Microbiol Immunol Hung. (2000)
- ^ Pas M, et al. Uptake of chromium(III) and chromium(VI) compounds in the yeast cell structure. Biometals. (2004)
- ^ a b Grant AP, McMullen JK. The effect of brewers yeast containing glucose tolerance factor on the response to treatment in Type 2 diabetics. A short controlled study. Ulster Med J. (1982)
- ^ Schwarz K, Mertz W. A glucose tolerance factor and its differentiation from factor 3. Arch Biochem Biophys. (1957)
- ^ Mirsky N, Weiss A, Dori Z. Chromium in biological systems, I. Some observations on glucose tolerance factor in yeast. J Inorg Biochem. (1980)
- ^ Weksler-Zangen S, et al. Glucose tolerance factor extracted from yeast: oral insulin-mimetic and insulin-potentiating agent: in vivo and in vitro studies. Br J Nutr. (2012)
- ^ Toepfer EW, et al. Preparation of chromium-containing material of glucose tolerance factor activity from brewer's yeast extracts and by synthesis. J Agric Food Chem. (1976)
- ^ a b c d Preuss HG, et al. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. J Med. (2000)
- ^ a b Thomas VL, Gropper SS. Effect of chromium nicotinic acid supplementation on selected cardiovascular disease risk factors. Biol Trace Elem Res. (1996)
- ^ Jain SK, et al. Effect of chromium dinicocysteinate supplementation on circulating levels of insulin, TNF-α, oxidative stress, and insulin resistance in type 2 diabetic subjects: randomized, double-blind, placebo-controlled study. Mol Nutr Food Res. (2012)
- ^ a b Hua Y, et al. Molecular mechanisms of chromium in alleviating insulin resistance. J Nutr Biochem. (2012)
- ^ a b Yamamoto A, Wada O, Ono T. Isolation of a biologically active low-molecular-mass chromium compound from rabbit liver. Eur J Biochem. (1987)
- ^ a b Vincent JB. Quest for the molecular mechanism of chromium action and its relationship to diabetes. Nutr Rev. (2000)
- ^ Yamamoto A, Wada O, Ono T. A low-molecular-weight, chromium-binding substance in mammals. Toxicol Appl Pharmacol. (1981)
- ^ a b Chen Y, et al. Characterization of the organic component of low-molecular-weight chromium-binding substance and its binding of chromium. J Nutr. (2011)
- ^ a b c Davis CM, Vincent JB. Chromium oligopeptide activates insulin receptor tyrosine kinase activity. Biochemistry. (1997)
- ^ a b Yamamoto A, Wada O, Manabe S. Evidence that chromium is an essential factor for biological activity of low-molecular-weight, chromium-binding substance. Biochem Biophys Res Commun. (1989)
- ^ a b Myers MG Jr, White MF. The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains. Diabetes. (1993)
- ^ Vincent JB. Recent advances in the nutritional biochemistry of trivalent chromium. Proc Nutr Soc. (2004)
- ^ Vincent JB. Chromium: celebrating 50 years as an essential element. Dalton Trans. (2010)
- ^ Rutter GA, Da Silva Xavier G, Leclerc I. Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem J. (2003)
- ^ Hardie DG. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev. (2011)
- ^ Zhao P, et al. A newly synthetic chromium complex-chromium (D-phenylalanine)3 activates AMP-activated protein kinase and stimulates glucose transport. Biochem Pharmacol. (2009)
- ^ a b Anderson RA, Kozlovsky AS. Chromium intake, absorption and excretion of subjects consuming self-selected diets. Am J Clin Nutr. (1985)
- ^ Bunker VW, et al. The uptake and excretion of chromium by the elderly. Am J Clin Nutr. (1984)
- ^ a b Chen NS, Tsai A, Dyer IA. Effect of chelating agents on chromium absorption in rats. J Nutr. (1973)
- ^ Hahn CJ, Evans GW. Absorption of trace metals in the zinc-deficient rat. Am J Physiol. (1975)
- ^ Laschinsky N, et al. Bioavailability of chromium(III)-supplements in rats and humans. Biometals. (2012)
- ^ a b c d e f g h Cefalu WT, et al. Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus. Metabolism. (2010)
- ^ HOPKINS LL Jr, SCHWARZ K. CHROMIUM (3) BINDING TO SERUM PROTEINS, SPECIFICALLY SIDEROPHILIN. Biochim Biophys Acta. (1964)
- ^ Ainscough EW, et al. Studies on human lactoferrin by electron paramagnetic resonance, fluorescence, and resonance Raman spectroscopy. Biochemistry. (1980)
- ^ a b Aisen P, Aasa R, Redfield AG. The chromium, manganese, and cobalt complexes of transferrin. J Biol Chem. (1969)
- ^ a b Sun Y, et al. The binding of trivalent chromium to low-molecular-weight chromium-binding substance (LMWCr) and the transfer of chromium from transferrin and chromium picolinate to LMWCr. J Biol Inorg Chem. (2000)
- ^ a b Yamamoto A, Wada O, Ono T. Distribution and chromium-binding capacity of a low-molecular-weight, chromium-binding substance in mice. J Inorg Biochem. (1984)
- ^ Harding C, Heuser J, Stahl P. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J Cell Biol. (1983)
- ^ a b c d Yoshida M, et al. Tissue accumulation and urinary excretion of chromium in rats fed diets containing graded levels of chromium chloride or chromium picolinate. J Toxicol Sci. (2010)
- ^ Seal CJ, Heaton FW. Effect of dietary picolinic acid on the metabolism of exogenous and endogenous zinc in the rat. J Nutr. (1985)
- ^ a b McCarty MF. Longevity effect of chromium picolinate--'rejuvenation' of hypothalamic function. Med Hypotheses. (1994)
- ^ Evans GW. Chromium picolinate is an efficacious and safe supplement. Int J Sport Nutr. (1993)
- ^ Mertz W. Chromium occurrence and function in biological systems. Physiol Rev. (1969)
- ^ Offenbacher EG, Pi-Sunyer FX. Beneficial effect of chromium-rich yeast on glucose tolerance and blood lipids in elderly subjects. Diabetes. (1980)
- ^ Offenbacher EG, Rinko CJ, Pi-Sunyer FX. The effects of inorganic chromium and brewer's yeast on glucose tolerance, plasma lipids, and plasma chromium in elderly subjects. Am J Clin Nutr. (1985)
- ^ a b c d Franklin M, Odontiadis J. Effects of treatment with chromium picolinate on peripheral amino acid availability and brain monoamine function in the rat. Pharmacopsychiatry. (2003)
- ^ McCarty MF. Enhancing central and peripheral insulin activity as a strategy for the treatment of endogenous depression--an adjuvant role for chromium picolinate. Med Hypotheses. (1994)
- ^ Hainer V, et al. Serotonin and norepinephrine reuptake inhibition and eating behavior. Ann N Y Acad Sci. (2006)
- ^ a b c d e f g Attenburrow MJ, et al. Chromium treatment decreases the sensitivity of 5-HT2A receptors. Psychopharmacology (Berl). (2002)
- ^ Horácek J, et al. The relationship between central serotonergic activity and insulin sensitivity in healthy volunteers. Psychoneuroendocrinology. (1999)
- ^ Palazidou E, et al. Noradrenaline uptake inhibition increases melatonin secretion, a measure of noradrenergic neurotransmission, in depressed patients. Psychol Med. (1992)
- ^ Pittler MH, Stevinson C, Ernst E. Chromium picolinate for reducing body weight: meta-analysis of randomized trials. Int J Obes Relat Metab Disord. (2003)
- ^ a b Docherty JP, et al. A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving. J Psychiatr Pract. (2005)
- ^ a b c Anton SD, et al. Effects of chromium picolinate on food intake and satiety. Diabetes Technol Ther. (2008)
- ^ Singh T, Williams K. Atypical depression. Psychiatry (Edgmont). (2006)
- ^ Brownley KA, et al. A double-blind, randomized pilot trial of chromium picolinate for binge eating disorder: results of the Binge Eating and Chromium (BEACh) study. J Psychosom Res. (2013)
- ^ a b c Krikorian R, et al. Improved cognitive-cerebral function in older adults with chromium supplementation. Nutr Neurosci. (2010)
- ^ Amann BL, et al. A 2-year, open-label pilot study of adjunctive chromium in patients with treatment-resistant rapid-cycling bipolar disorder. J Clin Psychopharmacol. (2007)
- ^ McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psychiatry. (1999)
- ^ a b Davidson JR, et al. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry. (2003)
- ^ Guallar E, et al. Low toenail chromium concentration and increased risk of nonfatal myocardial infarction. Am J Epidemiol. (2005)
- ^ a b Vrtovec M, et al. Chromium supplementation shortens QTc interval duration in patients with type 2 diabetes mellitus. Am Heart J. (2005)
- ^ Linnemann B, Janka HU. Prolonged QTc interval and elevated heart rate identify the type 2 diabetic patient at high risk for cardiovascular death. The Bremen Diabetes Study. Exp Clin Endocrinol Diabetes. (2003)
- ^ Okin PM, et al. Electrocardiographic repolarization complexity and abnormality predict all-cause and cardiovascular mortality in diabetes: the strong heart study. Diabetes. (2004)
- ^ a b Ghosh D, et al. Role of chromium supplementation in Indians with type 2 diabetes mellitus. J Nutr Biochem. (2002)
- ^ a b Jain SK, et al. Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes. Diabetes. (1989)
- ^ Jain SK, et al. Trivalent chromium inhibits protein glycosylation and lipid peroxidation in high glucose-treated erythrocytes. Antioxid Redox Signal. (2006)
- ^ a b c d e f g Abdollahi M, et al. Effect of chromium on glucose and lipid profiles in patients with type 2 diabetes; a meta-analysis review of randomized trials. J Pharm Pharm Sci. (2013)
- ^ Gastaldelli A, et al. Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans: a quantitative study. Diabetes. (2000)
- ^ a b c Pei D, et al. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism. (2006)
- ^ a b Wu GY, Wada O. Studies on a specific chromium binding substance (a low-molecular-weight chromium binding substance) in urine (author's transl). Sangyo Igaku. (1981)
- ^ Wada O, et al. Low-molecular-weight, chromium-binding substance in rat lungs and its possible role in chromium movement. Ind Health. (1983)
- ^ a b c d Wang H, Kruszewski A, Brautigan DL. Cellular chromium enhances activation of insulin receptor kinase. Biochemistry. (2005)
- ^ a b c d Mackowiak P, et al. Evaluation of insulin binding and signaling activity of newly synthesized chromium(III) complexes in vitro. Mol Med Rep. (2010)
- ^ Ukkola O, Santaniemi M. Protein tyrosine phosphatase 1B: a new target for the treatment of obesity and associated co-morbidities. J Intern Med. (2002)
- ^ Davis CM, Sumrall KH, Vincent JB. A biologically active form of chromium may activate a membrane phosphotyrosine phosphatase (PTP). Biochemistry. (1996)
- ^ Goldstein BJ, et al. Enhancement of post-receptor insulin signaling by trivalent chromium in hepatoma cells is associated with differential inhibition of specific protein-tyrosine phosphatases. J Trace Elem Exp Med. (2001)
- ^ a b c Wang ZQ, et al. Chromium picolinate enhances skeletal muscle cellular insulin signaling in vivo in obese, insulin-resistant JCR:LA-cp rats. J Nutr. (2006)
- ^ a b Aguirre V, et al. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem. (2000)
- ^ Solinas G, et al. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci U S A. (2006)
- ^ a b c Sreejayan N, et al. Chromium alleviates glucose intolerance, insulin resistance, and hepatic ER stress in obese mice. Obesity (Silver Spring). (2008)
- ^ a b Chen WY, et al. Chromium supplementation enhances insulin signalling in skeletal muscle of obese KK/HlJ diabetic mice. Diabetes Obes Metab. (2009)
- ^ Ozcan U, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. (2004)
- ^ Engin F, Hotamisligil GS. Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases. Diabetes Obes Metab. (2010)
- ^ Ozcan U, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. (2006)
- ^ Yang X, et al. Insulin-sensitizing and cholesterol-lowering effects of chromium (D-Phenylalanine)3. J Inorg Biochem. (2006)
- ^ Evans GW, Bowman TD. Chromium picolinate increases membrane fluidity and rate of insulin internalization. J Inorg Biochem. (1992)
- ^ Gorden P, et al. Intracellular translocation of iodine-125-labeled insulin: direct demonstration in isolated hepatocytes. Science. (1978)
- ^ McClain DA. Mechanism and role of insulin receptor endocytosis. Am J Med Sci. (1992)
- ^ Geiger D, et al. Down-regulation of insulin receptors is related to insulin internalization. Exp Cell Res. (1989)
- ^ Iqbal N, et al. Chromium picolinate does not improve key features of metabolic syndrome in obese nondiabetic adults. Metab Syndr Relat Disord. (2009)
- ^ Morino K, Petersen KF, Shulman GI. Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes. (2006)
- ^ Patal PC, Cardino MT, Jimeno CA. A meta-analysis on the effect of chromium picolinate on glucose and lipid profiles among patients with type 2 diabetes mellitus. Philipp J Intern Med. (2010)
- ^ a b Balk EM, et al. Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. Diabetes Care. (2007)
- ^ Broadhurst CL, Domenico P. Clinical studies on chromium picolinate supplementation in diabetes mellitus--a review. Diabetes Technol Ther. (2006)
- ^ a b c Frauchiger MT, Wenk C, Colombani PC. Effects of acute chromium supplementation on postprandial metabolism in healthy young men. J Am Coll Nutr. (2004)
- ^ Kleefstra N, et al. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care. (2007)
- ^ Kleefstra N, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care. (2006)
- ^ Lai MH. Antioxidant effects and insulin resistance improvement of chromium combined with vitamin C and e supplementation for type 2 diabetes mellitus. J Clin Biochem Nutr. (2008)
- ^ a b Martin J, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care. (2006)
- ^ Racek J, et al. Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus. Biol Trace Elem Res. (2006)
- ^ McIver DJ, et al. Risk of Type 2 Diabetes Is Lower in US Adults Taking Chromium-Containing Supplements. J Nutr. (2015)
- ^ Joseph LJ, et al. Effect of resistance training with or without chromium picolinate supplementation on glucose metabolism in older men and women. Metabolism. (1999)
- ^ a b Campbell WW, et al. Effects of resistive training and chromium picolinate on body composition and skeletal muscle size in older women. Int J Sport Nutr Exerc Metab. (2002)
- ^ Campbell WW, et al. Effects of resistance training and chromium picolinate on body composition and skeletal muscle in older men. J Appl Physiol (1985). (1999)
- ^ a b Walker LS, et al. Chromium picolinate effects on body composition and muscular performance in wrestlers. Med Sci Sports Exerc. (1998)
- ^ Hallmark MA, et al. Effects of chromium and resistive training on muscle strength and body composition. Med Sci Sports Exerc. (1996)
- ^ Livolsi JM, Adams GM, Laguna PL. The effect of chromium picolinate on muscular strength and body composition in women athletes. J Strength Cond Res. (2001)
- ^ a b c Davis JM, Welsh RS, Alerson NA. Effects of carbohydrate and chromium ingestion during intermittent high-intensity exercise to fatigue. Int J Sport Nutr Exerc Metab. (2000)
- ^ a b Volek JS, et al. Effects of chromium supplementation on glycogen synthesis after high-intensity exercise. Med Sci Sports Exerc. (2006)
- ^ Roginski EE, Mertz W. Effects of Chromium (III) Supplementation on Glucose and Amino Acid Metabolism in Rats Fed a Low Protein Diet. J Nutr.
- ^ Campbell WW, et al. Exercise training and dietary chromium effects on glycogen, glycogen synthase, phosphorylase and total protein in rats. J Nutr. (1989)
- ^ a b Tian H, et al. Chromium picolinate supplementation for overweight or obese adults. Cochrane Database Syst Rev. (2013)
- ^ Meyers AW, et al. Are weight concerns predictive of smoking cessation? A prospective analysis. J Consult Clin Psychol. (1997)
- ^ Rhee YS, et al. The effects of chromium and copper supplementation on mitogen-stimulated T cell proliferation in hypercholesterolaemic postmenopausal women. Clin Exp Immunol. (2002)
- ^ a b Cheng HH, et al. Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects. J Agric Food Chem. (2004)
- ^ a b Anderson RA, et al. Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus. J Am Coll Nutr. (2001)
- ^ Stearns DM, et al. Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells. FASEB J. (1995)
- ^ Parand A, et al. DNA nicking by a trinuclear chromium complex. Inorg. Chim. Acta. (1998)
- ^ Hassoun EA, Stohs SJ. Chromium-induced production of reactive oxygen species, DNA single-strand breaks, nitric oxide production, and lactate dehydrogenase leakage in J774A.1 cell cultures. J Biochem Toxicol. (1995)
- ^ Sugden KD, Geer RD, Rogers SJ. Oxygen radical-mediated DNA damage by redox-active Cr(III) complexes. Biochemistry. (1992)
- ^ Speetjens JK, et al. Low-molecular-weight chromium-binding substance and biomimetic {Cr3O(O2CCH2CH3)6(H2O)3}+ do not cleave DNA under physiologically-relevant conditions. Polyhedron. (1999)
- ^ a b Kato I, et al. Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil. Eur J Epidemiol. (1998)
- ^ Shirnamé-Moré L, et al. Genetic effects of 5-hydroxymethyl-2'-deoxyuridine, a product of ionizing radiation. Mutat Res. (1987)
- ^ a b Feng W, et al. Tissue contents and subcellular distribution of chromium and other trace metals in experimental diabetic rats after intravenous injection of Cr 50-enriched stable isotopic tracer solution. Metabolism. (2001)
- ^ Marouani N, et al. Effects of hexavalent chromium on reproductive functions of male adult rats. Reprod Biol. (2012)
- ^ Carette D, et al. Hexavalent chromium at low concentration alters Sertoli cell barrier and connexin 43 gap junction but not claudin-11 and N-cadherin in the rat seminiferous tubule culture model. Toxicol Appl Pharmacol. (2013)
- ^ Cheng RY, et al. Microarray analysis of altered gene expression in the TM4 Sertoli-like cell line exposed to chromium(III) chloride. Reprod Toxicol. (2002)
- ^ a b Mohamedshah FY, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr. (1998)
- ^ Kumpulainen J, et al. Dietary chromium intake of lactating Finnish mothers: effect on the Cr content of their breast milk. Br J Nutr. (1980)
- ^ a b c Anderson RA, et al. Breast milk chromium and its association with chromium intake, chromium excretion, and serum chromium.. Am J Clin Nutr. (1993)
- ^ Kumpulainen J, Vuori E. Longitudinal study of chromium in human milk.. Am J Clin Nutr. (1980)
- ^ a b Casey CE, Hambidge KM. Chromium in human milk from American mothers. Br J Nutr. (1984)
- ^ Mestre TA, Zurowski M, Fox SH. 5-Hydroxytryptamine 2A receptor antagonists as potential treatment for psychiatric disorders. Expert Opin Investig Drugs. (2013)
- ^ Hockney RA, et al. Lack of effect of chromium supplementation on mental state and body weight in people with schizophrenia. J Clin Psychopharmacol. (2006)
- ^ Lydic ML, et al. Chromium picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndrome. Fertil Steril. (2006)
- ^ Jamilian M, Asemi Z. Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Ann Nutr Metab. (2015)
- ^ Jamilian M, et al. The Effects of Chromium Supplementation on Endocrine Profiles, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Biol Trace Elem Res. (2016)
- ^ Yang J, Black J. Competitive binding of chromium, cobalt and nickel to serum proteins. Biomaterials. (1994)
- ^ Ani M, Moshtaghie AA. The effect of chromium on parameters related to iron metabolism. Biol Trace Elem Res. (1992)
- ^ Lukaski HC, Siders WA, Penland JG. Chromium picolinate supplementation in women: effects on body weight, composition, and iron status. Nutrition. (2007)
- ^ Król E, et al. Effects of chromium brewer's yeast supplementation on body mass, blood carbohydrates, and lipids and minerals in type 2 diabetic patients. Biol Trace Elem Res. (2011)
- ^ Preuss HG, Bagchi D, Bagchi M. Protective effects of a novel niacin-bound chromium complex and a grape seed proanthocyanidin extract on advancing age and various aspects of syndrome X. Ann N Y Acad Sci. (2002)
- ^ Diplock AT. Antioxidant nutrients and disease prevention: an overview. Am J Clin Nutr. (1991)
- ^ Campbell WW, et al. Resistive training and chromium picolinate: effects on inositols and liver and kidney functions in older adults. Int J Sport Nutr Exerc Metab. (2004)
- ^ Chen SY, Lien TF. Toxicity evaluation of chromium picolinate nanoparticles in vivo and in vitro in rat. Biol Trace Elem Res. (2013)
- ^ Anderson RA, Bryden NA, Polansky MM. Lack of toxicity of chromium chloride and chromium picolinate in rats. J Am Coll Nutr. (1997)
- ^ Cerulli J, et al. Chromium picolinate toxicity. Ann Pharmacother. (1998)
- ^ Martin WR, Fuller RE. Suspected chromium picolinate-induced rhabdomyolysis. Pharmacotherapy. (1998)
- Bahijiri SM, et al. The effects of inorganic chromium and brewer's yeast supplementation on glucose tolerance, serum lipids and drug dosage in individuals with type 2 diabetes. Saudi Med J. (2000)
- Anderson RA, et al. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes. (1997)
- Kim CW, et al. Effects of short-term chromium supplementation on insulin sensitivity and body composition in overweight children: randomized, double-blind, placebo-controlled study. J Nutr Biochem. (2011)
- Feiner JJ, et al. Chromium picolinate for insulin resistance in subjects with HIV disease: a pilot study. Diabetes Obes Metab. (2008)
- Gunton JE, et al. Chromium supplementation does not improve glucose tolerance, insulin sensitivity, or lipid profile: a randomized, placebo-controlled, double-blind trial of supplementation in subjects with impaired glucose tolerance. Diabetes Care. (2005)
- Paiva AN, et al. Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study. J Trace Elem Med Biol. (2015)
- Yazaki Y, et al. A pilot study of chromium picolinate for weight loss. J Altern Complement Med. (2010)
- Ali A, et al. Chromium effects on glucose tolerance and insulin sensitivity in persons at risk for diabetes mellitus. Endocr Pract. (2011)
- Sharma S, et al. Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes. J Trace Elem Med Biol. (2011)
- Aghdassi E, et al. In patients with HIV-infection, chromium supplementation improves insulin resistance and other metabolic abnormalities: a randomized, double-blind, placebo controlled trial. Curr HIV Res. (2010)
- Brownley KA, et al. Chromium supplementation for menstrual cycle-related mood symptoms. J Diet Suppl. (2013)
Â
Â
Â