Calcium
Overview
Calcium is a mineral that is an essential part of bones and teeth. The heart, nerves, and blood-clotting systems also need calcium to work.
Calcium is commonly taken by mouth for the treatment and prevention of low calcium levels. It is also used for conditions linked with low calcium levels including muscle cramps (latent tetany), osteoporosis (weak bones due to low bone density), rickets (a condition in children involving softening of the bones), and osteomalacia (a softening of bones involving pain). Calcium is sometimes taken by mouth to reduce high levels of the parathyroid hormone (hyperparathyroidism) and for symptoms of premenstrual syndrome (PMS) along with many other conditions.
Calcium carbonate is taken by mouth as an antacid for "heartburn." Calcium carbonate and calcium acetate are also taken by mouth to reduce phosphate levels in people with kidney disease.
Calcium is also used as a mouth rinse to prevent and reduce pain and swelling inside of the mouth following chemotherapy. Calcium is given intravenously (by IV) for very low calcium levels of the blood and related symptoms. It is also used for high potassium levels in the blood.
Calcium-rich foods include milk and dairy products, kale and broccoli, as well as the calcium-enriched citrus juices, mineral water, canned fish with bones, and soy products processed with calcium.
Calcium can interact with many prescription medications, but sometimes the effects can be minimized by taking calcium at a different time. See the section titled "Are there any interactions with medications?"
Classification
Is a Form of:
Mineral
Primary Functions:
Treatment and Prevention of low calcium levels
Also Known As:
Calcium Acetate, Calcium Aspartate, Calcium Carbonate, Calcium Chelate
How Does It Work?
The bones and teeth contain over 99% of the calcium in the human body. Calcium is also found in the blood, muscles, and other tissue. Calcium in the bones can be used as a reserve that can be released into the body as needed. The concentration of calcium in the body tends to decline as we age because it is released from the body through sweat, skin cells, and waste. In addition, as women age, absorption of calcium tends to decline due to reduced estrogen levels. Calcium absorption can vary depending on race, gender, and age.
Bones are always breaking down and rebuilding, and calcium is needed for this process. Taking extra calcium helps the bones rebuild properly and stay strong.
Uses
- Indigestion (dyspepsia). Taking calcium carbonate by mouth as an antacid is effective for treating indigestion.
- High levels of potassium in the blood (hyperkalemia). Giving calcium gluconate intravenously (by IV) can reverse heart problems caused by hyperkalemia, a condition in which there is too much potassium in the blood.
- Low levels of calcium in the blood (hypocalcemia). Taking calcium by mouth is effective for treating and preventing hypocalcemia. Also, giving calcium intravenously (by IV) is effective for treating very low levels of calcium.
- Kidney failure. Taking calcium carbonate or calcium acetate by mouth is effective for controlling high phosphate levels in the blood in people with kidney failure. Calcium citrate is not effective for treating this condition. Taking calcium by mouth also seems to be helpful for reducing blood pressure in people with kidney failure.
- Bone loss in people taking drugs called corticosteroids. Taking calcium along with vitamin D seems to reduce the loss of bone mineral in people using corticosteroid drugs long-term.
- Overactive parathyroid (hyperparathyroidism). Taking calcium by mouth reduces parathyroid hormone levels in people with kidney failure and parathyroid hormone levels that are too high.
- Weak and brittle bones (osteoporosis). Taking calcium by mouth is effective for preventing bone loss and treating osteoporosis. Most bone growth occurs in the teenage years. After that, bone strength in women remains about the same until age 30-40. After age 40, bone loss typically occurs at rates of 0.5% to 1% per year. In men, this bone loss occurs several decades later. Bone loss is greater in people getting less than the recommended amount of calcium from their diet. This is very common among Americans. Bone loss in women over 40 can be reduced by taking calcium supplements. Some researchers estimate that taking calcium for 30 years after menopause might result in a 10% improvement in bone strength. Taking calcium alone or with vitamin D also helps prevent fractures in people with osteoporosis.
- Premenstrual syndrome (PMS). There seems to be a link between low dietary calcium intake and symptoms of PMS. Consuming calcium daily seems to significantly reduce mood swings, bloating, food cravings, and pain. Also, increasing the amount of calcium in one's diet seems to prevent PMS. Women consuming an average of 1283 mg/day of calcium from foods seem to have about a 30% lower risk of PMS than women who consume an average of 529 mg/day of calcium.
- Colon cancer, rectal cancer. Research suggests that high intake of calcium in the diet or as a supplement reduces the risk of colorectal cancer. But not all research agrees. People with low levels of vitamin D do not seem to benefit from calcium supplements. People who are overweight or obese also seem to be less likely to benefit from calcium supplements.
- Increasing bone strength in the unborn baby. In pregnant women who eat a low amount of calcium as part of their diet, calcium supplementation increases the bone mineral density of the fetus. However, this does not appear to be beneficial for women with normal calcium levels.
- A condition caused by ingestion of too much fluoride (fluorosis). Taking calcium by mouth, together with vitamin C and vitamin D supplements, seems to reduce fluoride levels in children and improve symptoms of fluoride poisoning.
- High cholesterol. Taking calcium supplements along with a low-fat or low-calorie diet seems to modestly reduce low-density lipoprotein (LDL) or "bad" cholesterol and modestly increase high-density lipoprotein (HDL) or "good" cholesterol. Taking calcium alone, without the restricted diet, does not seem to lower cholesterol.
- High blood pressure. Taking calcium supplements seems to reduce blood pressure by a small amount (usually around 1-2 mmHg) in people with or without high blood pressure. Calcium seems to work best in salt-sensitive people and people who normally get very little calcium. Some research also suggests that taking calcium might reduce the risk of having high blood pressure.
- A pregnancy complication marked by high blood pressure and protein in the urine (pre-eclampsia). Taking 1-2 grams of calcium by mouth daily seems to reduce the risk of pregnancy-related high blood pressure. Calcium appears to have the greatest effect in high-risk women, in women with low calcium levels, and when started by the 20th week of pregnancy.
- Softening of bones in children, often due to vitamin D deficiency (rickets). Rickets is mostly commonly due to vitamin D deficiency, but very low calcium intake can also cause rickets.
- Preventing tooth loss (tooth retention). Taking calcium and vitamin D by mouth appears to help prevent tooth loss in older people.
Recommended Dosing
The following doses have been studied in scientific research:
BY MOUTH:
- For preventing low calcium levels: 1-2 grams elemental calcium daily is typically used. Sometimes it is taken with 800 IU of vitamin D.
- For heartburn: 0.5-1.5 grams of calcium carbonate is used as needed.
- To reduce phosphates in adults with chronic renal failure: 1-6.5 grams per day of calcium carbonate or calcium acetate has been used. The daily dose is divided up and taken between meals.
- For preventing weak bones (osteoporosis) caused by corticosteroid use: Divided daily doses of 0.5-1 gram of elemental calcium daily.
- For reducing parathyroid hormone levels (hyperparathyroidism): 1.2-4 grams of calcium, usually as a carbonate salt. Often it is used in combination with a low-phosphate diet or 800 IU of vitamin D.
- For prevention of weak bones (osteoporosis): Most experts recommend taking 1000-1200 mg of calcium daily to prevent osteoporosis and broken bones.
- For increasing fetal bone density in pregnant women with low dietary calcium intake: 300-2000 mg/day, taken during the second and third trimesters.
- For premenstrual syndrome (PMS): 1-1.3 grams per day as calcium carbonate.
- For preventing colorectal cancer and recurrent colorectal benign tumors (adenomas): Up to 2 grams daily.
- For high cholesterol: 800 mg daily for up to 2 years. Calcium 1200 mg taken in 2-3 divided doses daily, alone or in combination with vitamin D 400 IU daily, has also been used in conjunction with a low-fat or calorie-restricted diet for up to 15 weeks.
- For preventing high blood pressure during pregnancy (pre-eclampsia): 1-2 grams elemental calcium daily as calcium carbonate.
- For high blood pressure: Up to 0.4-2 grams daily for up to 4 years
- For preventing tooth loss in elderly people: 500 mg of calcium along with 700 IU of vitamin D daily for 3 years.
- For weight loss: Calcium 800-1200 mg daily with or without a calorie-restricted diet has been used. In some cases, calcium is taken in combination with 400 IU of vitamin D.
INTRAVENOUS (BY IV):
- For low calcium levels in the blood: 100-200 mg of calcium is given as a bolus dose
- For high potassium levels in the blood: 20 mL of 10% calcium gluconate is administered over 5-10 minutes in most adults. In adults taking digoxin, the dose is administered over 20-30 minutes.
CHILDREN
BY MOUTH
- For preventing fluoride poisoning: Calcium 125 mg twice daily, in combination with ascorbic acid and vitamin D.
- High blood pressure: 1.5 grams per day for 8 weeks has been used in adolescents.
INTRAVENOUS
- For high potassium levels in the blood: 0.5 mL of 10% calcium gluconate is administered over 5-10 minutes.
Calcium carbonate and calcium citrate are the two most commonly used forms of calcium.
Calcium supplements are usually divided into two doses daily in order to increase absorption. It's best to take calcium with food in doses of 500 mg or less.
The Institute of Medicine publishes a recommended daily allowance (RDA) for calcium which is an estimate of the intake level necessary to meet the requirements of nearly all healthy individuals in the population. The current RDA was set in 2010. The RDA varies based on age as follows: Age 1-3 years, 700 mg; 4-8 years, 1000 mg; 9-18 years, 1300 mg; 19-50 years, 1000 mg; Men 51-70 years, 1000 mg; Women 51-70 years, 1200 mg; 70+ years, 1200 mg; Pregnant or Lactating (under 19 years), 1300 mg; Pregnant or Lactating (19-50 years), 1000 mg.
The Institute of Medicine also sets the daily tolerable upper intake level (UL) for calcium based on age as follows: Age 0-6 months, 1000 mg; 6-12 months, 1500 mg; 1-3 years, 2500 mg; 9-18 years, 3000 mg; 19-50 years, 2500 mg; 51+ years, 2000 mg. Doses above these levels should be avoided.
Doses over the recommended daily intake level of 1000-1300 mg/day for most adults have been associated with an increased risk of heart attack. Until more is known, continue consuming adequate amounts of calcium to meet daily requirements, but not excessive amounts of calcium. Be sure to consider total calcium intake from both dietary and supplemental sources and try not to exceed 1000-1300 mg of calcium per day. To figure out dietary calcium, count 300 mg/day from non-dairy foods plus 300 mg/cup of milk or fortified orange juice.
Calcium Supplements Frequently Asked Questions
What is the best form of calcium to take?
Calcium carbonate and calcium citrate are the optimal forms of supplement. Calcium carbonate should be taken with meals because it requires stomach acid to dissolve and absorb. Calcium carbonate has the most calcium per pill (40 percent), therefore fewer pills are needed.
Can calcium supplements be harmful?
“The truth is, the research is inconclusive. But there is a growing body of evidence that suggests no health benefit, or even worse, that calcium supplements may be harmful.” Multiple studies have found that there's little to no benefit to taking calcium supplements for the prevention of hip fractures.
Can I take calcium tablet daily?
In general, it's best to take calcium supplements with food. For better absorption, don't take more than 500 milligrams at one time. Split up larger doses over the course of the day. For the body to make use of calcium properly, you also need to get enough vitamin D and magnesium.
When should you take calcium supplements?
To maximize your absorption of calcium, take no more than 500 mg at a time. You might take one 500 mg supplement in the morning and another at night. If you take a supplement that also contains vitamin D, it will help your body absorb calcium more efficiently.
What are the side effects of taking calcium with vitamin D?
- an irregular heartbeat
- nausea, vomiting, or decreased appetite
- dry mouth
- constipation
- weakness
- headache
- a metallic taste
- muscle or bone pain
What are the side effects of calcium tablets?
Side effects.
At normal doses, calcium supplements may cause bloating, gas, and constipation. Very high doses of calcium can cause kidney stones.
Who should not take calcium supplements?
33 For healthy children, there has been no recommendation for routine calcium supplementation. In clinical practice, children with a high risk of osteoporosis (eg, celiac disease, inflammatory bowel disease, or congenital bone disorder) or low calcium intake may benefit from calcium supplementation.
How much calcium should a 60 year old woman take daily?
The National Osteoporosis Foundation recommends that women aged 50 or younger and men 70 or younger should get 1,000 milligrams (mg) of calcium per day. Men and women older than that should get 1,200 mg daily.
What is the safest calcium supplement to take?
Calcium citrate supplements are absorbed more easily than calcium carbonate. They can be taken on an empty stomach and are more readily absorbed by people who take acid-reducing heartburn medications. But because calcium citrate is only 21% calcium, you may need to take more tablets to get your daily requirement.
What are the symptoms of lack of calcium?
- confusion or memory loss.
- muscle
- numbness and tingling in the hands, feet, and face.
- muscle
- weak and brittle nails.
- easy fracturing of the bones.
Does calcium tablets increase weight?
Data suggest that a diet deficient in calcium is associated with higher body weight and that augmenting calcium intake may reduce weight and fat gain or enhance loss. Calcium supplementation did not significantly affect amount of weight or fat lost by women counseled to follow a moderately restricted diet for 25 wk.
What are the symptoms of calcium deficiency in adults?
Signs and Symptoms of Calcium Deficiency
- Tingling Fingers.
- Muscle
- Poor appetite.
- Weak or brittle fingernails.
- Difficulty swallowing.
Does taking calcium at night help you sleep?
William Sears, M.D. writes: "Calcium helps the brain use the amino acid tryptophan to manufacture the sleep-inducing substance melatonin. This explains why dairy products, which contain both tryptophan and calcium, are one of the top sleep-inducing foods."
Can you take vitamin D and calcium together?
While your body needs vitamin D to absorb calcium, you do not need to take vitamin D at the same time as a calcium supplement.
What is the best form of calcium to take for osteoporosis?
The two most commonly used calcium products are calcium carbonate and calcium citrate. Calcium carbonate supplements dissolve better in an acid environment, so they should be taken with a meal. Calcium citrate supplements can be taken any time because they do not need acid to dissolve.
Why you shouldn't take calcium supplements?
On the other hand, recent studies have linked calcium supplements with an increased risk of colon polyps (small growths in the large intestine that can become cancerous) and kidney stones, which are hard masses usually formed in the kidneys from an accumulation of calcium and other substances.
When should you take calcium tablets morning or night?
To maximize your absorption of calcium, take no more than 500 mg at a time. You might take one 500 mg supplement in the morning and another at night. If you take a supplement that also contains vitamin D, it will help your body absorb calcium more efficiently.
Is taking calcium bad for the heart?
After analyzing 10 years of medical tests on more than 2,700 people in a federally funded heart disease study, researchers at Johns Hopkins Medicine and elsewhere conclude that taking calcium in the form of supplements may raise the risk of plaque buildup in arteries and heart damage, although a diet high in calcium
What is the best calcium supplement for seniors?
The Right Calcium Supplement for Senior Citizens
- Calcium This form of calciumis considered easy to absorb.
- Calcium Rolaids and TUMS both contain calciumcarbonate.
- Calciumwith Vitamin D.
- The Best Calcium Supplementfor You.
- CalciumQuality, Purity and Potency.
- Calcium
- Calciumand Other Medications.
How do you increase calcium in old age?
Calcium Intake for Adults over Age 55
- Dairy products, such as cheese, milk and yogurt.
- Dark green leafy vegetables, such as broccoli and kale.
- Fish with edible soft bones, such as sardines and canned salmon.
- Calcium-fortified foods and beverages, such as soy products, cereal and fruit juices, and milk substitutes.
Clinical Studies
- ^ a b c d Straub DA. Calcium supplementation in clinical practice: a review of forms, doses, and indications. Nutr Clin Pract. (2007)
- ^ a b Lewis JR, Zhu K, Prince RL. Adverse events from calcium supplementation: relationship to errors in myocardial infarction self-reporting in randomized controlled trials of calcium supplementation. J Bone Miner Res. (2012)
- ^ a b Mao PJ, et al. Effect of calcium or vitamin D supplementation on vascular outcomes: a meta-analysis of randomized controlled trials. Int J Cardiol. (2013)
- ^ a b Bolland MJ, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ. (2010)
- ^ a b Bolland MJ, et al. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ. (2011)
- ^ Khajehei M, et al. Effect of treatment with dydrogesterone or calcium plus vitamin D on the severity of premenstrual syndrome. Int J Gynaecol Obstet. (2009)
- ^ Booth A, Camacho P. A Closer look at calcium absorption and the benefits and risks of dietary versus supplemental calcium. Postgrad Med. (2013)
- ^ a b Lanham-New SA. Importance of calcium, vitamin D and vitamin K for osteoporosis prevention and treatment. Proc Nutr Soc. (2008)
- ^ Prakasam M et al.. Fabrication, Properties and Applications of Dense Hydroxyapatite: A Review. J Funct Biomater. (2015)
- ^ Jacobson J, Duchen MR. Interplay between mitochondria and cellular calcium signalling. Mol Cell Biochem. (2004)
- ^ a b c Dietary Reference Intakes for Calcium and Vitamin D.
- ^ a b c Ross AC et al.. The 2011 Dietary Reference Intakes for Calcium and Vitamin D: what dietetics practitioners need to know. J Am Diet Assoc. (2011)
- ^ Rajakumar K. Vitamin D, cod-liver oil, sunlight, and rickets: a historical perspective. Pediatrics. (2003)
- ^ a b Pettifor JM. Nutritional rickets: deficiency of vitamin D, calcium, or both?. Am J Clin Nutr. (2004)
- ^ Kooh SW et al.. Rickets due to calcium deficiency. N Engl J Med. (1977)
- ^ Legius E et al.. Rickets due to dietary calcium deficiency. Eur J Pediatr. (1989)
- ^ Majid Molla A et al.. Risk factors for nutritional rickets among children in Kuwait. Pediatr Int. (2000)
- ^ Pettifor JM et al.. Rickets in children of rural origin in South Africa: is low dietary calcium a factor?. J Pediatr. (1978)
- ^ a b Effects of dietary calcium and phosphate on the intestinal interactions between calcium, phosphate, fatty acids, and bile acids.
- ^ Trautvetter U, Kiehntopf M, Jahreis G. Postprandial effects of calcium phosphate supplementation on plasma concentration-double-blind, placebo-controlled cross-over human study. Nutr J. (2013)
- ^ Grimm M, et al. High phosphorus intake only slightly affects serum minerals, urinary pyridinium crosslinks and renal function in young women. Eur J Clin Nutr. (2001)
- ^ Ishitani K et al.. Calcium absorption from the ingestion of coral-derived calcium by humans. J Nutr Sci Vitaminol (Tokyo). (1999)
- ^ Kim SK, Ravichandran YD, Kong CS. Applications of calcium and its supplement derived from marine organism. Crit Rev Food Sci Nutr. (2012)
- ^ Ramos AA, Inoue Y, Ohde S. Metal contents in Porites corals: Anthropogenic input of river run-off into a coral reef from an urbanized area, Okinawa. Mar Pollut Bull. (2004)
- ^ J. Hu et al.. Production and analysis of hydroxyapatite from Australian corals via hydrothermal process. Journal of Materials Science Letters. (2001)
- ^ Reddy PN, Lakshmana M, Udupa UV. Effect of Praval bhasma (Coral calx), a natural source of rich calcium on bone mineralization in rats. Pharmacol Res. (2003)
- ^ Banu J et al.. Dietary coral calcium and zeolite protects bone in a mouse model for postmenopausal bone loss. Nutr Res. (2012)
- ^ a b Hendy GN, Canaff L. Calcium-sensing receptor, proinflammatory cytokines and calcium homeostasis. Semin Cell Dev Biol. (2016)
- ^ Canaff L, Zhou X, Hendy GN. The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3. J Biol Chem. (2008)
- ^ Canaff L, Hendy GN. Calcium-sensing receptor gene transcription is up-regulated by the proinflammatory cytokine, interleukin-1beta. Role of the NF-kappaB PATHWAY and kappaB elements. J Biol Chem. (2005)
- ^ a b Bronner F. Mechanisms of intestinal calcium absorption. J Cell Biochem. (2003)
- ^ a b c Diaz de Barboza G, Guizzardi S, Tolosa de Talamoni N. Molecular aspects of intestinal calcium absorption. World J Gastroenterol. (2015)
- ^ a b Bronner F, Pansu D, Stein WD. An analysis of intestinal calcium transport across the rat intestine. Am J Physiol. (1986)
- ^ a b Bronner F, Buckley M. Calcium-binding protein biosynthesis in the rat: Regulation by calcium and 1,25-dihydroxyvitamin D3. Arch Biochem and Biophys. (1980)
- ^ Alexander RT, Rievaj J, Dimke H. Paracellular calcium transport across renal and intestinal epithelia. Biochem Cell Biol. (2014)
- ^ Peng JB et al. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J Biol Chem. (1999)
- ^ Nijenhuis T et al.. Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney. J Am Soc Nephrol. (2003)
- ^ a b Kellett GL. Alternative perspective on intestinal calcium absorption: proposed complementary actions of Ca(v)1.3 and TRPV6. Nutr Rev. (2011)
- ^ Nägerl UV et al.. Binding kinetics of calbindin-D(28k) determined by flash photolysis of caged Ca(2+). Biophys J. (2000)
- ^ Schwaller B. Cytosolic Ca2+ buffers. Cold Spring Harb Perspect Biol. (2010)
- ^ Centeno VA et al.. Dietary calcium deficiency increases Ca2+ uptake and Ca2+ extrusion mechanisms in chick enterocytes. Comp Biochem Physiol A Mol Integr Physiol. (2004)
- ^ Ghijsen WE, De Jong MD, Van Os CH. Kinetic properties of Na+/Ca2+ exchange in basolateral plasma membranes of rat small intestine. Biochim Biophys Acta. (1983)
- ^ Freeman TC et al.. Cellular and regional expression of transcripts of the plasma membrane calcium pump PMCA1 in rabbit intestine. Am J Physiol. (1995)
- ^ Favus MJ. Factors that influence absorption and secretion of calcium in the small intestine and colon. Am J Physiol. (1985)
- ^ Pansu D et al. Solubility and intestinal transit time limit calcium absorption in rats. J Nutr. (1993)
- ^ Celotti F, Bignamini A. Dietary calcium and mineral/vitamin supplementation: a controversial problem. J Int Med Res. (1999)
- ^ Miller GD, Jarvis JK, McBean LD. The importance of meeting calcium needs with foods. J Am Coll Nutr. (2001)
- ^ Wigertz K, et al. Racial differences in calcium retention in response to dietary salt in adolescent girls. Am J Clin Nutr. (2005)
- ^ Heaney RP, Recker RR, Saville PD. Menopausal changes in calcium balance performance. J Lab Clin Med. (1978)
- ^ Heaney RP, et al. Calcium absorption in women: relationships to calcium intake, estrogen status, and age. J Bone Miner Res. (1989)
- ^ Wolf RL, et al. Factors associated with calcium absorption efficiency in pre- and perimenopausal women. Am J Clin Nutr. (2000)
- ^ Pattanaungkul S, et al. Relationship of intestinal calcium absorption to 1,25-dihydroxyvitamin D 1,25(OH)2D levels in young versus elderly women: evidence for age-related intestinal resistance to 1,25(OH)2D action. J Clin Endocrinol Metab. (2000)
- ^ Cifuentes M, et al. Weight loss and calcium intake influence calcium absorption in overweight postmenopausal women. Am J Clin Nutr. (2004)
- ^ O'Brien KO, et al. Calcium absorption is significantly higher in adolescents during pregnancy than in the early postpartum period. Am J Clin Nutr. (2003)
- ^ Vargas Zapata CL, et al. Calcium homeostasis during pregnancy and lactation in Brazilian women with low calcium intakes: a longitudinal study. Am J Clin Nutr. (2004)
- ^ Cross NA, et al. Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: a longitudinal study. Am J Clin Nutr. (1995)
- ^ Kalkwarf HJ, et al. Intestinal calcium absorption of women during lactation and after weaning. Am J Clin Nutr. (1996)
- ^ Ritchie LD, et al. A longitudinal study of calcium homeostasis during human pregnancy and lactation and after resumption of menses. Am J Clin Nutr. (1998)
- ^ Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA. (1998)
- ^ a b c d e f g Yetley EA. Multivitamin and multimineral dietary supplements: definitions, characterization, bioavailability, and drug interactions. Am J Clin Nutr. (2007)
- ^ Jones BJ, Twomey PJ. Requesting patterns for serum calcium concentration in patients on long-term lithium therapy. Int J Clin Pract. (2009)
- ^ a b c Govers MJ, et al. Calcium in milk products precipitates intestinal fatty acids and secondary bile acids and thus inhibits colonic cytotoxicity in humans. Cancer Res. (1996)
- ^ Van der Meer R, et al. Mechanisms of the intestinal effects of dietary fats and milk products on colon carcinogenesis. Cancer Lett. (1997)
- ^ a b c Ditscheid B, Keller S, Jahreis G. Faecal steroid excretion in humans is affected by calcium supplementation and shows gender-specific differences. Eur J Nutr. (2009)
- ^ Renaud S, et al. Nutrients, platelet function and composition in nine groups of French and British farmers. Atherosclerosis. (1986)
- ^ Rao RM, Yan Y, Wu Y. Dietary calcium reduces blood pressure, parathyroid hormone, and platelet cytosolic calcium responses in spontaneously hypertensive rats. Am J Hypertens. (1944)
- ^ Oshima T, et al. Modification of platelet and lymphocyte calcium handling and blood pressure by dietary sodium and calcium in genetically hypertensive rats. J Lab Clin Med. (1992)
- ^ Uysal KT, et al. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology. (2000)
- ^ Makowski L, et al. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med. (2001)
- ^ Schlottmann I, et al. Calcium-dependent release of adipocyte fatty acid binding protein from human adipocytes. Int J Obes (Lond). (2014)
- ^ a b Kida R, et al. Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes. Cell Biochem Funct. (20016)
- ^ Gepner AD, et al. Comparison of coronary artery calcium presence, carotid plaque presence, and carotid intima-media thickness for cardiovascular disease prediction in the Multi-Ethnic Study of Atherosclerosis. Circ Cardiovasc Imaging. (2015)
- ^ Folsom AR, et al. Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA). Arch Intern Med. (2008)
- ^ a b Uemura H, et al. Association between dietary calcium intake and arterial stiffness according to dietary vitamin D intake in men. Br J Nutr. (2014)
- ^ Pivin E, et al. Inactive Matrix Gla-Protein Is Associated With Arterial Stiffness in an Adult Population-Based Study. Hypertension. (2015)
- ^ Wright NC et al.. The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine. J Bone Miner Res. (2014)
- ^ Bailey RL et al.. Estimation of total usual calcium and vitamin D intakes in the United States. J Nutr. (2010)
- ^ Wallace TC et al.. Calcium and vitamin D disparities are related to gender, age, race, household income level, and weight classification but not vegetarian status in the United States: Analysis of the NHANES 2001-2008 data set. J Am Coll Nutr. (2013)
- ^ Ensrud KE. Epidemiology of fracture risk with advancing age. J Gerontol A Biol Sci Med Sci. (2013)
- ^ Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet. (2002)
- ^ Karinkanta S et al.. Combined resistance and balance-jumping exercise reduces older women's injurious falls and fractures: 5-year follow-up study. Age Ageing. (2015)
- ^ a b Bolland MJ et al. Calcium intake and risk of fracture: systematic review. BMJ. (2015)
- ^ Lau EM, et al. Milk supplementation of the diet of postmenopausal Chinese women on a low calcium intake retards bone loss. J Bone Miner Res. (2001)
- ^ Chevalley T et al.. Effects of calcium supplements on femoral bone mineral density and vertebral fracture rate in vitamin-D-replete elderly patients. Osteoporos Int. (1994)
- ^ Weaver CM et al.. Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int. (2016)
- ^ Cinar V, et al. Testosterone levels in athletes at rest and exhaustion: effects of calcium supplementation. Biol Trace Elem Res. (2009)
- ^ Nagengast FM, Grubben MJ, van Munster IP. Role of bile acids in colorectal carcinogenesis. Eur J Cancer. (1995)
- ^ Roberton AM. Roles of endogenous substances and bacteria in colorectal cancer. Mutat Res. (1993)
- ^ Glinghammar B, Inoue H, Rafter JJ. Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1. Carcinogenesis. (2002)
- ^ Powolny A, Xu J, Loo G. Deoxycholate induces DNA damage and apoptosis in human colon epithelial cells expressing either mutant or wild-type p53. Int J Biochem Cell Biol. (2001)
- ^ Differential binding of glycine- and taurine-conjugated bile acids to insoluble calcium phosphate.
- ^ Govers MJ, et al. Characterization of the adsorption of conjugated and unconjugated bile acids to insoluble, amorphous calcium phosphate. J Lipid Res. (1994)
- ^ Termine JD, Posner AS. Calcium phosphate formation in vitro. I. Factors affecting initial phase separation. Arch Biochem Biophys. (1970)
- ^ Villar J, et al. Strategies to prevent and treat preeclampsia: evidence from randomized controlled trials. Semin Nephrol. (2004)
- ^ Belizán JM, Villar J, Repke J. The relationship between calcium intake and pregnancy-induced hypertension: up-to-date evidence. Am J Obstet Gynecol. (1988)
- ^ Segovia BL, et al. Hypocalciuria during pregnancy as a risk factor of preeclampsia. Ginecol Obstet Mex. (2004)
- ^ Kumru S, et al. Comparison of serum copper, zinc, calcium, and magnesium levels in preeclamptic and healthy pregnant women. Biol Trace Elem Res. (2003)
- ^ Isezuo SA, Ekele BA. Eclampsia and abnormal QTc. West Afr J Med. (2004)
- ^ a b Hofmeyr GJ, et al. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev. (2014)
- ^ Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ. (2005)
- ^ Sibai BM, et al. Risk factors associated with preeclampsia in healthy nulliparous women. The Calcium for Preeclampsia Prevention (CPEP) Study Group. Am J Obstet Gynecol. (1997)
- ^ Gillman MW et al.. Maternal calcium intake and offspring blood pressure. Circulation. (2004)
- ^ McGarvey ST et al.. Maternal prenatal dietary potassium, calcium, magnesium, and infant blood pressure. Hypertension. (1991)
- ^ Jamshidi F, Kelishadi R. A systematic review on the effects of maternal calcium supplementation on offspring's blood pressure. J Res Med Sci. (2015)
- ^ Hatton DC, et al. Gestational calcium supplementation and blood pressure in the offspring. Am J Hypertens. (2003)
- ^ Belizán JM et al.. Long-term effect of calcium supplementation during pregnancy on the blood pressure of offspring: follow up of a randomised controlled trial. BMJ. (1997)
- ^ a b Hiller JE et al.. Calcium supplementation in pregnancy and its impact on blood pressure in children and women: follow up of a randomised controlled trial. Aust N Z J Obstet Gynaecol. (2007)
- ^ a b Hawkesworth S et al.. Effect of maternal calcium supplementation on offspring blood pressure in 5- to 10-y-old rural Gambian children. Am J Clin Nutr. (2010)
- ^ a b Crowther CA, et al. Calcium supplementation in nulliparous women for the prevention of pregnancy-induced hypertension, preeclampsia and preterm birth: an Australian randomized trial. FRACOG and the ACT Study Group. Aust N Z J Obstet Gynaecol. (1999)
- ^ Malpeli A, et al. Calcium supplementation, bone mineral density and bone mineral content. Predictors of bone mass changes in adolescent mothers during the 6-month postpartum period. Arch Latinoam Nutr. (2012)
- ^ a b c Wargovich MJ, Eng VW, Newmark HL. Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett. (1984)
- ^ Lipkin M. Biomarkers of increased susceptibility to gastrointestinal cancer: new application to studies of cancer prevention in human subjects. Cancer Res. (1988)
- ^ Sorenson AW, Slattery ML, Ford MH. Calcium and colon cancer: a review. Nutr Cancer. (1988)
- ^ Steinbach G, et al. Effect of calcium supplementation on rectal epithelial hyperproliferation in intestinal bypass subjects. Gastroenterology. (1994)
- ^ Lipkin M, et al. Colonic epithelial cell proliferation in responders and nonresponders to supplemental dietary calcium. Cancer Res. (1989)
- ^ a b Mineo H, Hara H, Tomita F. Sugar alcohols enhance calcium transport from rat small and large intestine epithelium in vitro. Dig Dis Sci. (2002)
- ^ Mineo H et al.. Two-week feeding of difructose anhydride III enhances calcium absorptive activity with epithelial cell proliferation in isolated rat cecal mucosa. Nutrition. (2006)
- ^ Saito K et al.. Effects of DFA IV in rats: calcium absorption and metabolism of DFA IV by intestinal microorganisms. Biosci Biotechnol Biochem. (1999)
- ^ Hara H, Suzuki T, Aoyama Y. Ingestion of the soluble dietary fibre, polydextrose, increases calcium absorption and bone mineralization in normal and total-gastrectomized rats. Br J Nutr. (2000)
- ^ Levrat MA, Rémésy C, Demigné C. High propionic acid fermentations and mineral accumulation in the cecum of rats adapted to different levels of inulin. J Nutr. (1991)
- ^ Younes H, Demigné C, Rémésy C. Acidic fermentation in the caecum increases absorption of calcium and magnesium in the large intestine of the rat. Br J Nutr. (1996)
- ^ Duflos C, et al. Calcium solubility, intestinal sojourn time and paracellular permeability codetermine passive calcium absorption in rats. J Nutr. (1995)
- ^ Reid IR, Bristow SM, Bolland MJ. Calcium supplements: benefits and risks. J Intern Med. (2015)
- ^ Edward RA, Szabo NJ, Tebbett IR. Lead Content of Calcium Supplements. JAMA. (2000)
- ^ Kern J, et al. Calcium supplementation and risk of dementia in women with cerebrovascular disease. Neurology. (2016)
- ^ a b Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs. (1999)
- ^ Chan JM, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden). Cancer Causes Control. (1998)
- ^ Tseng M, et al. Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort. Am J Clin Nutr. (2005)
- ^ a b Giovannucci E, et al. A prospective study of calcium intake and incident and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev. (2006)
- ^ Tavani A, et al. Dietary intake of calcium, vitamin D, phosphorus and the risk of prostate cancer. Eur Urol. (2005)
- ^ Lee WT, et al. A follow-up study on the effects of calcium-supplement withdrawal and puberty on bone acquisition of children. Am J Clin Nutr. (1996)
- ^ Lambert HL, et al. Calcium supplementation and bone mineral accretion in adolescent girls: an 18-mo randomized controlled trial with 2-y follow-up. Am J Clin Nutr. (2008)
- ^ Pronisceva V, et al. A case report on over-replacement of oral calcium supplements causing acute pancreatitis. Ann R Coll Surg Engl. (2014)
- ^ Kato Y, et al. Hypercalcemia induced by excessive intake of calcium supplement, presenting similar findings of primary hyperparathyroidism. Endocr J. (2004)
- ^ Picolos MK, Orlander PR. Calcium carbonate toxicity: the updated milk-alkali syndrome; report of 3 cases and review of the literature. Endocr Pract. (2005)
- ^ Cameron HU. Calcium supplements and arthritis. CMAJ. (1988)
- ^ Caplan RH, Miller CD, Silva PD. Severe hypercalcemia in a lactating woman in association with moderate calcium carbonate supplementation: a case report. J Reprod Med. (2004)
- ^ Koletzko B, et al. Intestinal milk-bolus obstruction in formula-fed premature infants given high doses of calcium. J Pediatr Gastroenterol Nutr. (1988)
- ^ Lameris AL, et al. Importance of dietary calcium and vitamin D in the treatment of hypercalcaemia in Williams-Beuren syndrome. J Pediatr Endocrinol Metab. (2014)
- ^ Vanpee D, et al. Ingestion of antacid tablets (Rennie) and acute confusion. J Emerg Med. (2000)
- ^ Renie WA, et al. Pseudoxanthoma elasticum: high calcium intake in early life correlates with severity. Am J Med Genet. (1984)
- Hawkesworth S, et al. Effect of maternal calcium supplementation on offspring blood pressure in 5- to 10-y-old rural Gambian children. Am J Clin Nutr. (2010)
- Villar J, et al. World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women. Am J Obstet Gynecol. (2006)
- Hiller JE, et al. Calcium supplementation in pregnancy and its impact on blood pressure in children and women: follow up of a randomised controlled trial. Aust N Z J Obstet Gynaecol. (2007)
- Belizán JM, et al. Long-term effect of calcium supplementation during pregnancy on the blood pressure of offspring: follow up of a randomised controlled trial. BMJ. (1997)
- Shobeiri F, et al. Effect of calcium on premenstrual syndrome: A double-blind randomized clinical trial. Obstet Gynecol Sci. (2017)
- Masoumi SZ, Ataollahi M, Oshvandi K. Effect of Combined Use of Calcium and Vitamin B6 on Premenstrual Syndrome Symptoms: a Randomized Clinical Trial. J Caring Sci. (2016)
- Yonkers KA, Pearlstein TB, Gotman N. A pilot study to compare fluoxetine, calcium, and placebo in the treatment of premenstrual syndrome. J Clin Psychopharmacol. (2013)
- Ghanbari Z, et al. Effects of calcium supplement therapy in women with premenstrual syndrome. Taiwan J Obstet Gynecol. (2009)
- Thys-Jacobs S, et al. Calcium carbonate and the premenstrual syndrome: effects on premenstrual and menstrual symptoms. Premenstrual Syndrome Study Group. Am J Obstet Gynecol. (1998)
- Thys-Jacobs S, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med. (1989)
- Penland JG, Johnson PE. Dietary calcium and manganese effects on menstrual cycle symptoms. Am J Obstet Gynecol. (1993)