Overview

Astaxanthin is a reddish pigment that belongs to a group of chemicals called carotenoids. It occurs naturally in certain algae and causes the pink or red color in salmon, trout, lobster, shrimp, and other seafood.

Astaxanthin is taken by mouth for treating Alzheimer's disease, Parkinson's disease, stroke, high cholesterol, liver diseases, age-related macular degeneration (age-related vision loss), and preventing cancer. It is also used for metabolic syndrome, which is a group of conditions that increase the risk of heart disease, stroke and diabetes. It is also used for improving exercise performance, decreasing muscle damage after exercise, and decreasing muscle soreness after exercise. Also, astaxanthin is taken by mouth to prevent sunburn, to improve sleep, and for carpal tunnel syndrome, dyspepsia, male infertility, symptoms of menopause, and rheumatoid arthritis.

Astaxanthin is applied directly to the skin to protect against sunburn, to reduce wrinkles, and for other cosmetic benefits.

In food, it is used as a coloring for salmon, crabs, shrimp, chicken, and egg production.

In agriculture, astaxanthin is used as a food supplement for egg-producing chickens.

Classification

Is a Form of:

Pigment that belongs to a group of chemicals called carotenoids

Primary Functions:

Alzheimer’s disease, Parkinson disease, stroke, high cholesterol

Also Known As:

Astaxanthine, Astaxantina, Dihydroxy-3,3’ dioxo-4,4’ bêta-carotène, Microalgae

How Does It Work?

Astaxanthin is an antioxidant. This effect might protect cells from damage. Astaxanthin might also improve the way the immune system functions.

Uses

• Age-related vision loss (age-related macular degeneration; AMD). AMD occurs when a portion of retina becomes damaged. Early research shows that taking a product containing astaxanthin, lutein, zeaxanthin, vitamin E, vitamin C, zinc, and copper by mouth improves damage in the center of the retina in people with AMD. It does not improve damage in the outer areas of the retina.
• Carpal tunnel syndrome. Early research shows that taking a combination product containing astaxanthin, lutein, beta-carotene, and vitamin E by mouth does not reduce pain in people with carpal tunnel syndrome.
• Indigestion (dyspepsia). Early research shows that taking 40 mg of astaxanthin daily reduces reflux symptoms in people with indigestion. It seems to work best in people with indigestion due to H. pylori infection. A lower dose of 16 mg daily does not improve reflux symptoms. Neither dose reduces stomach pain, indigestion, or the amount of H. pylori bacteria in the stomach of people with indigestion.
• Muscle damage caused by exercise. Early research shows that taking astaxanthin for 90 days does not reduce muscle damage caused by exercise in male soccer players.
• Muscle soreness caused by exercise. Early research shows that taking a product containing astaxanthin, lutein, and safflower oil by mouth does not reduce muscle soreness or improve muscle performance 4 days after exercise compared to taking only safflower oil.
• Exercise performance. Research regarding the effects of astaxanthin on exercise performance is conflicting. Some early research shows that taking astaxanthin decreases the time needed to complete a cycling exercise in trained male athletes. But other research shows that using astaxanthin does not improve the time needed to complete a timed exercise.
• Fatigue. Early research shows that taking a product containing astaxanthin and sesamin does not seem to improve overall fatigue in healthy adults.
• High cholesterol. Early research shows that taking astaxanthin by mouth reduces blood fats called triglycerides and increases high-density lipoprotein (HDL or "good") cholesterol in people with high cholesterol. Other early research shows that taking a combination of astaxanthin, berberine, policosanol, red yeast rice, coenzyoeme Q10, and folic acid increases HDL cholesterol levels and lowers total cholesterol, low-density lipoprotein (LDL or "bad") cholesterol, and triglycerides in people with abnormal cholesterol levels.
• Male infertility. Early research shows that taking astaxanthin increases the pregnancy rates of partners of men considered to be infertile.
• Menopausal symptoms. Early research shows that taking a product containing astaxanthin, vitamin D3, lycopene, and citrus bioflavonoids daily reduces menopausal symptoms such as hot flashes, joint pain, moodiness, and bladder problems.
• Rheumatoid arthritis (RA). Early research shows that taking a product containing astaxanthin, lutein, vitamin A, vitamin E, and safflower oil reduces pain and improves feelings of satisfaction in people with RA.
• Sunburn. Astaxanthin might reduce skin damage caused by the sun. Taking astaxanthin by mouth for 9 weeks appears to reduce redness and loss of skin moisture caused by rays of the sun called "UV" rays.
• Wrinkled skin. Early research shows that taking astaxanthin by mouth improves how quickly skin bounces back (elasticity) and reduces fine lines and wrinkles in middle-aged women and men. It also seems to improve the moisture content in the skin. Other research shows that taking astaxanthin by mouth, along with applying astaxanthin cream to the face twice daily, improves the appearance of skin wrinkles.

Recommended Dosing

The appropriate dose of astaxanthin depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for astaxanthin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Astaxanthin Supplements Frequently Asked Questions

What is astaxanthin supplement good for?

Astaxanthin is taken by mouth for treating Alzheimer's disease, Parkinson's disease, stroke, high cholesterol, liver diseases, age-related macular degeneration (age-related vision loss), and preventing cancer. In agriculture, astaxanthin is used as a food supplement for egg-producing chickens.

When should I take astaxanthin?

Pharmacokinetic research has been conducted using 40 mg[3] or 100 mg of asta per day[4]. They specify that the best absorption of astaxanthin is in the presence of lipids. It is therefore recommended to consume it during or just after a meal[5].

What is the best source of astaxanthin?

Most of those natural sources of astaxanthin can be found at your local grocery store, including sockeye salmon, red trout, lobster, shrimp, crawfish, crab, salmon roe, and red sea bream.

Does astaxanthin make you gain weight?

Natural astaxanthin has been shown to inhibit weight-gain and other markers linked with a high fat diet. However, a program that combines sensible food intake levels, exercise routine with natural astaxanthin makes such goal a realistic one.

Can you take astaxanthin everyday?

Astaxanthin is POSSIBLY SAFE when taken by mouth as a supplement. Astaxanthin has been used safely by itself in doses of 4 to 40 mg daily for up to 12 weeks, or 12 mg daily for 6 months. It has been used safely in combination with other carotenoids, vitamins, and minerals at 4 mg daily for up to 12 months.

How long does it take to see results from astaxanthin?

As with any supplement, the degree to which you'd notice an effect really depends on the nutrient status of the individual at the time. However, research on astaxanthin suggests that positive effects are seen and felt within about four weeks.

Should I take astaxanthin in the morning or at night?

Reminder: it is recommended to take chlorella in the morning on an empty stomach, spirulina in the evening before the meal. Astaxanthin is best taken during or after a meal because it is best assimilated in the presence of lipids.

Is astaxanthin safe for kidneys?

One of the most common complications associated with DM is nephropathy or kidney damage. Even though the previous studies demonstrated that astaxanthin could suppress ROS and reduce nephropathy, the mechanism remained unclear to how astaxanthin could reduce renal damage until now.

Does astaxanthin help hair growth?

Astaxanthin reduces inflammation on the scalp

Astaxanthin is an antioxidant and red carotenoid pigment found in algae, salmon, lobster and shrimp, giving them their pink hue. Astaxanthin's anti-inflammatory properties can help reduce inflammation chemicals on the scalp which may be inhibiting hair growth.

Is astaxanthin good for your liver?

In a 2016 study, Jui-Tung Chen and his team at the Jichi Medical University in Japan found that astaxanthin use can help protect the liver function and prevent fatty liver disease, cancerous disease, and cardiovascular disease.

Is astaxanthin safe to take?

Astaxanthin is LIKELY SAFE when it is consumed in amounts found in food. Astaxanthin is POSSIBLY SAFE when taken by mouth as a supplement. Astaxanthin has been used safely by itself in doses of 4 to 40 mg daily for up to 12 weeks, or 12 mg daily for 6 months. High doses of astaxanthin may cause stomach pain.

Where can I get astaxanthin naturally?

The natural sources of astaxanthin are algae, yeast, salmon, trout, krill, shrimp and crayfish.  The commercial astaxanthin is mainly from Phaffia yeast, Haematococcus and through chemical synthesis.

What are the side effects of taking astaxanthin?

Side effects of astaxanthin may include increased bowel movements and red stool color. High doses of astaxanthin may cause stomach pain.

Does astaxanthin darken skin?

Astaxanthin protects the skin against oxidation, not only preventing the aging process, but also potentially reversing external signs of aging. Astaxanthin also helps lighten dark spots. It is a potent protection against ultraviolet radiation, assisting the skin in protecting itself against damage by the sun.

Does astaxanthin give you a tan?

Turns out, it can have the same effect on your body. Fournier says, As studies suggest, it has been my experience that astaxanthin acts as a natural internal sunscreen protecting you from further UV damage and helping to diminish skin pigmentation.

Does astaxanthin really work?

The anti-inflammatory properties of astaxanthin are owed to is antioxidant tendencies. In a study published in the Journal of Investigative Ophthalmology & Visual Science, researchers found that astaxanthin is effective against oxidative stress caused by nitric oxide.

Will astaxanthin turn you pink?

When you consume astaxanthin, you become more resistant to turning pink – from the sun. It's like an inside-out sunscreen, especially if you're prone to sunburns. Astaxanthin accumulates in every layer of the skin to protect your skin from burns and sun damage.

How much astaxanthin should I take a day?

Astaxanthin Dosage

For that reason, there is currently no set recommended daily intake for astaxanthin. Clinical trials so far have used astaxanthin doses ranging from 1 mg per day to 40 mg per day. But the majority of trials have used a dose of astaxanthin between 6 mg per day and 12 mg per day.

Does astaxanthin boost immune system?

Natural astaxanthin seems to improve the immune response by increasing the number of antibody producing cells. Natural astaxanthin enhances antibody production, and may also protect immune cells against oxidative stress and membrane damage.

Is astaxanthin better than CoQ10?

Astaxanthin outperforms CoQ10 800 times over in fighting free radicals. In the realm of cognitive function, astaxanthin can provide powerful benefits due to its effectiveness in reducing oxidative stress.

Does astaxanthin increase testosterone?

One small study showed astaxanthin combined with saw palmetto actually increased testosterone, which could help libido. More research is needed to better understand astaxanthin's effects on hormones. Astaxanthin may also lower blood pressure and calcium levels.

Does astaxanthin give you energy?

And astaxanthin is an antioxidant powerhouse, delivering benefits across the entire human body, including your skin, cardiovascular system and brain, while also providing much needed energy support. Much of its strength derives from the fact that its ability to fight free radicals is 6,000-times higher than vitamin C.

Clinical Studies

• ^ a b c Belcaro G, et al. MF Afragil® in the treatment of 34 menopause symptoms: a pilot study. Panminerva Med. (2010)
• ^ Bloomer RJ, et al. Astaxanthin supplementation does not attenuate muscle injury following eccentric exercise in resistance-trained men. Int J Sport Nutr Exerc Metab. (2005)
• ^ Astaxanthin as a Medical Food.
• ^ The carotenoids of the carapace of the echinoderm Ophidiaster ophidianus.
• ^ a b Carotenoid Distribution in Living Cells of Haematococcus pluvialis (Chlorophyceae).
• ^ a b Sandmann G. Carotenoid biosynthesis in microorganisms and plants. Eur J Biochem. (1994)
• ^ a b c d Hussein G, et al. Astaxanthin, a carotenoid with potential in human health and nutrition. J Nat Prod. (2006)
• ^ a b c d e Fassett RG, Coombes JS. Astaxanthin: a potential therapeutic agent in cardiovascular disease. Mar Drugs. (2011)
• ^ Garama D, Bremer P, Carne A. Extraction and analysis of carotenoids from the New Zealand sea urchin Evechinus chloroticus gonads. Acta Biochim Pol. (2012)
• ^ a b Guerin M, Huntley ME, Olaizola M. Haematococcus astaxanthin: applications for human health and nutrition. Trends Biotechnol. (2003)
• ^ Antioxidant role of astaxanthin in the green alga Haematococcus pluvialis.
• ^ a b Recent advances in industrial carotenoid synthesis.
• ^ Khan SK, et al. Novel astaxanthin prodrug (CDX-085) attenuates thrombosis in a mouse model. Thromb Res. (2010)
• ^ a b Jackson H, Braun CL, Ernst H. The chemistry of novel xanthophyll carotenoids. Am J Cardiol. (2008)
• ^ a b c Coral-Hinostroza GN, et al. Plasma appearance of unesterified astaxanthin geometrical E/Z and optical R/S isomers in men given single doses of a mixture of optical 3 and 3'R/S isomers of astaxanthin fatty acyl diesters. Comp Biochem Physiol C Toxicol Pharmacol. (2004)
• ^ Østerlie M, Bjerkeng B, Liaaen-Jensen S. Plasma appearance and distribution of astaxanthin E/Z and R/S isomers in plasma lipoproteins of men after single dose administration of astaxanthin. J Nutr Biochem. (2000)
• ^ Krinsky NI. Antioxidant functions of carotenoids. Free Radic Biol Med. (1989)
• ^ Quantitative assessment of antioxidant properties of natural colorants and phytochemicals: carotenoids, flavonoids, phenols and indigoids. The role of β-carotene in antioxidant functions.
• ^ Woodall AA, Britton G, Jackson MJ. Carotenoids and protection of phospholipids in solution or in liposomes against oxidation by peroxyl radicals: relationship between carotenoid structure and protective ability. Biochim Biophys Acta. (1997)
• ^ a b c d e McNulty HP, et al. Differential effects of carotenoids on lipid peroxidation due to membrane interactions: X-ray diffraction analysis. Biochim Biophys Acta. (2007)
• ^ May JM. Is ascorbic acid an antioxidant for the plasma membrane. FASEB J. (1999)
• ^ Jyonouchi H, et al. Astaxanthin, a carotenoid without vitamin A activity, augments antibody responses in cultures including T-helper cell clones and suboptimal doses of antigen. J Nutr. (1995)
• ^ Sangeetha RK, Baskaran V. Retinol-deficient rats can convert a pharmacological dose of astaxanthin to retinol: antioxidant potential of astaxanthin, lutein, and β-carotene. Can J Physiol Pharmacol. (2010)
• ^ van Het Hof KH, et al. Dietary factors that affect the bioavailability of carotenoids. J Nutr. (2000)
• ^ Erdman JW Jr, Bierer TL, Gugger ET. Absorption and transport of carotenoids. Ann N Y Acad Sci. (1993)
• ^ Roodenburg AJ, et al. Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans. Am J Clin Nutr. (2000)
• ^ Mercke Odeberg J, et al. Oral bioavailability of the antioxidant astaxanthin in humans is enhanced by incorporation of lipid based formulations. Eur J Pharm Sci. (2003)
• ^ a b c d e Okada Y, Ishikura M, Maoka T. Bioavailability of astaxanthin in Haematococcus algal extract: the effects of timing of diet and smoking habits. Biosci Biotechnol Biochem. (2009)
• ^ Goulinet S, Chapman MJ. Plasma LDL and HDL subspecies are heterogenous in particle content of tocopherols and oxygenated and hydrocarbon carotenoids. Relevance to oxidative resistance and atherogenesis. Arterioscler Thromb Vasc Biol. (1997)
• ^ Romanchik JE, Morel DW, Harrison EH. Distributions of carotenoids and alpha-tocopherol among lipoproteins do not change when human plasma is incubated in vitro. J Nutr. (1995)
• ^ Showalter LA, et al. Plasma appearance and tissue accumulation of non-esterified, free astaxanthin in C57BL/6 mice after oral dosing of a disodium disuccinate diester of astaxanthin (Heptax). Comp Biochem Physiol C Toxicol Pharmacol. (2004)
• ^ Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev. (2011)
• ^ Miyazawa T, et al. Plasma carotenoid concentrations before and after supplementation with astaxanthin in middle-aged and senior subjects. Biosci Biotechnol Biochem. (2011)
• ^ a b c d e Choi HD, et al. Effects of astaxanthin on oxidative stress in overweight and obese adults. Phytother Res. (2011)
• ^ a b Choi HD, et al. Pharmacokinetics and first-pass metabolism of astaxanthin in rats. Br J Nutr. (2011)
• ^ Rüfer CE, et al. Bioavailability of astaxanthin stereoisomers from wild (Oncorhynchus spp.) and aquacultured (Salmo salar) salmon in healthy men: a randomised, double-blind study. Br J Nutr. (2008)
• ^ Saw CL, et al. Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the NRF2-ARE pathway. Food Chem Toxicol. (2013)
• ^ Kim JH, et al. Astaxanthin Improves Stem Cell Potency via an Increase in the Proliferation of Neural Progenitor Cells. Int J Mol Sci. (2010)
• ^ Gill MS. Endocrine targets for pharmacological intervention in aging in Caenorhabditis elegans. Aging Cell. (2006)
• ^ Finding function in novel targets: C. elegans as a model organism.
• ^ a b Supplemental Cellular Protection by a Carotenoid Extends Lifespan via Ins/IGF-1 Signaling in Caenorhabditis elegans.
• ^ Yanase S, et al. SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation. J Gerontol A Biol Sci Med Sci. (2009)
• ^ Murphy CT, et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. (2003)
• ^ Lauver DA, Driscoll EM, Lucchesi BR. Disodium disuccinate astaxanthin prevents carotid artery rethrombosis and ex vivo platelet activation. Pharmacology. (2008)
• ^ Gross GJ, Lockwood SF. Cardioprotection and myocardial salvage by a disodium disuccinate astaxanthin derivative (Cardax). Life Sci. (2004)
• ^ Gross GJ, Hazen SL, Lockwood SF. Seven day oral supplementation with Cardax (disodium disuccinate astaxanthin) provides significant cardioprotection and reduces oxidative stress in rats. Mol Cell Biochem. (2006)
• ^ Gross GJ, Lockwood SF. Acute and chronic administration of disodium disuccinate astaxanthin (Cardax) produces marked cardioprotection in dog hearts. Mol Cell Biochem. (2005)
• ^ Lockwood SF, Gross GJ. Disodium disuccinate astaxanthin (Cardax): antioxidant and antiinflammatory cardioprotection. Cardiovasc Drug Rev. (2005)
• ^ Hussein G, et al. Antihypertensive and neuroprotective effects of astaxanthin in experimental animals. Biol Pharm Bull. (2005)
• ^ Hussein G, et al. Antihypertensive potential and mechanism of action of astaxanthin: III. Antioxidant and histopathological effects in spontaneously hypertensive rats. Biol Pharm Bull. (2006)
• ^ Chitchumroonchokchai C, et al. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. J Nutr. (2004)
• ^ Singlet oxygen quenching ability of astaxanthin esters from the green alga Haematococcus pluvialis.
• ^ Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol. (1996)
• ^ a b c Hussein G, et al. Astaxanthin ameliorates features of metabolic syndrome in SHR/NDmcr-cp. Life Sci. (2007)
• ^ Pashkow FJ, Watumull DG, Campbell CL. Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. Am J Cardiol. (2008)
• ^ Valko M, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. (2007)
• ^ Tak PP, Firestein GS. NF-kappaB: a key role in inflammatory diseases. J Clin Invest. (2001)
• ^ a b c Miyazawa T, et al. Erythrocytes carotenoids after astaxanthin supplementation in middle-aged and senior Japanese subjects. J Oleo Sci. (2011)
• ^ a b c Nakagawa K, et al. Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. Br J Nutr. (2011)
• ^ Nakagawa K, et al. Antioxidant effect of lutein towards phospholipid hydroperoxidation in human erythrocytes. Br J Nutr. (2009)
• ^ a b Miyawaki H, et al. Effects of astaxanthin on human blood rheology. J Clin Biochem Nutr. (2008)
• ^ a b c d e f g h i Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. (2011)
• ^ a b c d e f g Yoshida H, et al. Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis. (2010)
• ^ Naito Y, et al. Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice. Biofactors. (2004)
• ^ Manabe E, et al. Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling. J Cell Biochem. (2008)
• ^ Okamoto Y, et al. Adiponectin: a key adipocytokine in metabolic syndrome. Clin Sci (Lond). (2006)
• ^ Adiponectin Reduces Plasma Triglyceride by Increasing VLDL Triglyceride Catabolism.
• ^ a b Aoi W, et al. Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification. Biochem Biophys Res Commun. (2008)
• ^ a b Djordjevic B, et al. Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players. J Sports Med Phys Fitness. (2012)
• ^ a b Earnest CP, et al. Effect of astaxanthin on cycling time trial performance. Int J Sports Med. (2011)
• ^ Choi SK, et al. Effects of astaxanthin on the production of NO and the expression of COX-2 and iNOS in LPS-stimulated BV2 microglial cells. J Microbiol Biotechnol. (2008)
• ^ Ohgami K, et al. Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Invest Ophthalmol Vis Sci. (2003)
• ^ Nakano M, et al. Effect of astaxanthin in combination with alpha-tocopherol or ascorbic acid against oxidative damage in diabetic ODS rats. J Nutr Sci Vitaminol (Tokyo). (2008)
• ^ Lee SJ, et al. Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation. Mol Cells. (2003)
• ^ Mieszczanska H, et al. Gender-related differences in electrocardiographic parameters and their association with cardiac events in patients after myocardial infarction. Am J Cardiol. (2008)
• ^ a b Iwamoto T, et al. Inhibition of low-density lipoprotein oxidation by astaxanthin. J Atheroscler Thromb. (2000)
• ^ Karppi J, et al. Effects of astaxanthin supplementation on lipid peroxidation. Int J Vitam Nutr Res. (2007)
• ^ a b Li Z, et al. Astaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase II enzymes through activation of PI3K/Akt. Mol Vis. (2013)
• ^ Wang L, et al. Essential roles of the PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE. Invest Ophthalmol Vis Sci. (2008)
• ^ Block G, et al. Factors associated with oxidative stress in human populations. Am J Epidemiol. (2002)
• ^ Olusi SO. Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans. Int J Obes Relat Metab Disord. (2002)
• ^ a b Angwafor F 3rd, Anderson ML. An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males. J Int Soc Sports Nutr. (2008)
• ^ Anderson ML. A preliminary investigation of the enzymatic inhibition of 5alpha-reduction and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and Saw Palmetto lipid extract in vitro. J Herb Pharmacother. (2005)
• ^ a b c Comhaire FH, et al. Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: a double blind, randomized trial. Asian J Androl. (2005)
• ^ Parisi V, et al. Carotenoids and antioxidants in age-related maculopathy italian study: multifocal electroretinogram modifications after 1 year. Ophthalmology. (2008)
• ^ Santocono M, et al. Influence of astaxanthin, zeaxanthin and lutein on DNA damage and repair in UVA-irradiated cells. J Photochem Photobiol B. (2006)
• ^ a b Otsuka T, et al. The Protective Effects of a Dietary Carotenoid, Astaxanthin, Against Light-Induced Retinal Damage. J Pharmacol Sci. (2013)
• ^ Santocono M, et al. Lutein, zeaxanthin and astaxanthin protect against DNA damage in SK-N-SH human neuroblastoma cells induced by reactive nitrogen species. J Photochem Photobiol B. (2007)
• ^ a b c d e f Nakajima Y, et al. Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo. J Pharm Pharmacol. (2008)
• ^ a b c Izumi-Nagai K, et al. Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin. Invest Ophthalmol Vis Sci. (2008)
• ^ Izumi-Nagai K, et al. Macular pigment lutein is antiinflammatory in preventing choroidal neovascularization. Arterioscler Thromb Vasc Biol. (2007)
• ^ Koto T, et al. Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice. Invest Ophthalmol Vis Sci. (2007)
• ^ Lopez PF, et al. Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration. Am J Ophthalmol. (1991)
• ^ Rosenfeld PJ, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. (2006)
• ^ Sakurai E, et al. Macrophage depletion inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. (2003)
• ^ Tsutsumi C, et al. The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization. J Leukoc Biol. (2003)
• ^ Kratsovnik E, et al. Oxidative stress activates transcription factor NF-kB-mediated protective signaling in primary rat neuronal cultures. J Mol Neurosci. (2005)
• ^ Helenius M, et al. Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle. J Mol Cell Cardiol. (1996)
• ^ Cort A, et al. Suppressive effect of astaxanthin on retinal injury induced by elevated intraocular pressure. Regul Toxicol Pharmacol. (2010)
• ^ Saito M, et al. Astaxanthin increases choroidal blood flow velocity. Graefes Arch Clin Exp Ophthalmol. (2012)
• ^ a b Galan P, et al. Serum concentrations of beta-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population. Eur J Clin Nutr. (2005)
• ^ a b c Tominaga K, et al. Cosmetic benefits of astaxanthin on humans subjects. Acta Biochim Pol. (2012)
• ^ Eskenazi B, et al. Antioxidant intake is associated with semen quality in healthy men. Hum Reprod. (2005)
• ^ Garrido N, et al. Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility. Asian J Androl. (2004)
• ^ Sanocka D, Kurpisz M. Reactive oxygen species and sperm cells. Reprod Biol Endocrinol. (2004)
• ^ The influence of age and lead exposure on inhibin B serum levels in men.
• ^ Meachem SJ, Nieschlag E, Simoni M. Inhibin B in male reproduction: pathophysiology and clinical relevance. Eur J Endocrinol. (2001)
• ^ Spiller GA, Dewell A. Safety of an astaxanthin-rich Haematococcus pluvialis algal extract: a randomized clinical trial. J Med Food. (2003)
• ^ Serebruany V, et al. The in vitro effects of Xancor, a synthetic astaxanthine derivative, on hemostatic biomarkers in aspirin-naïve and aspirin-treated subjects with multiple risk factors for vascular disease. Am J Ther. (2010)
• ^ Fassett RG, et al. Astaxanthin vs placebo on arterial stiffness, oxidative stress and inflammation in renal transplant patients (Xanthin): a randomised controlled trial. BMC Nephrol. (2008)
• ^ Park JS, et al. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab (Lond). (2010)
• Kim JH, et al. Protective effects of Haematococcus astaxanthin on oxidative stress in healthy smokers. J Med Food. (2011)
• Baralic I, et al. Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. Evid Based Complement Alternat Med. (2015)
• Petyaev IM, et al. Markers of Hypoxia and Oxidative Stress in Aging Volunteers Ingesting Lycosomal Formulation of Dark Chocolate Containing Astaxanthin. J Nutr Health Aging. (2018)
• Ito N, Seki S, Ueda F. The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. (2018)
• Tominaga K, et al. Protective effects of astaxanthin on skin deterioration. J Clin Biochem Nutr. (2017)
• Mashhadi NS, et al. Astaxanthin improves glucose metabolism and reduces blood pressure in patients with type 2 diabetes mellitus. Asia Pac J Clin Nutr. (2018)
• Coombes JS, Sharman JE, Fassett RG. Astaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial). Am J Clin Nutr. (2016)
• Macdermid JC, et al. A blinded placebo-controlled randomized trial on the use of astaxanthin as an adjunct to splinting in the treatment of carpal tunnel syndrome. Hand (N Y). (2012)
• Res PT, et al. Astaxanthin supplementation does not augment fat use or improve endurance performance. Med Sci Sports Exerc. (2013)
• Kupcinskas L, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled study. Phytomedicine. (2008)
• Andersen LP, et al. Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin. FEMS Immunol Med Microbiol. (2007)
• Chen JT, Kotani K. Effects of Astaxanthin on Liver and Leukocyte Parameters in Healthy Climacteric Women: Preliminary Data. J Med Food. (2017)